Draxin, a repulsive axon guidance protein, is involved in hippocampal development

Sanbing Zhang; Yuhong Su; Yohei Shinmyo; Shahidul M. Islam; Iftekhar Bin Naser; Giasuddin Ahmed; Nobuaki Tamamaki; Hideaki Tanaka

doi:10.1016/j.neures.2009.09.1710

Draxin, a repulsive axon guidance protein, is involved in hippocampal development

Sanbing Zhang, Yuhong Su, Yohei Shinmyo, Shahidul M. Islam, Iftekhar Bin Naser, Giasuddin Ahmed, Nobuaki Tamamaki, Hideaki Tanaka^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

The hippocampus plays an essential role in learning and memory and is one of the major sites implicated in neural diseases. The proper organization of the hippocampus during development is important for its function. We found that draxin, a repulsive axon guidance cue, was widely expressed in the developing hippocampus and draxin deficient mice possessed a smaller hippocampus, particularly in the anterior part of the structure. Quantification of this reduction revealed that the volume of the dentate gyrus of the mutant was significantly smaller compared to the normal counterpart. This size reduction seemed to be dependent on apoptosis rather than due to a decrease in the rate of cell division. (C) 2009 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

Original language	English
Pages (from-to)	53-61
Number of pages	9
Journal	Neuroscience Research
Volume	66
Issue number	1
DOIs	https://doi.org/10.1016/j.neures.2009.09.1710
Publication status	Published - Jan 2010
Externally published	Yes

Keywords

Repulsive axon guidance protein
Draxin
Knockout mouse
Hippocampus
Cell death
Dentate gyrus
DENTATE-GYRUS
CELL-PROLIFERATION
GRANULE CELLS
EXPRESSION
NEUROGENESIS
FOREBRAIN
MIGRATION
REELIN
GROWTH
DIFFERENTIATION

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10.1016/j.neures.2009.09.1710

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title = "Draxin, a repulsive axon guidance protein, is involved in hippocampal development",

abstract = "The hippocampus plays an essential role in learning and memory and is one of the major sites implicated in neural diseases. The proper organization of the hippocampus during development is important for its function. We found that draxin, a repulsive axon guidance cue, was widely expressed in the developing hippocampus and draxin deficient mice possessed a smaller hippocampus, particularly in the anterior part of the structure. Quantification of this reduction revealed that the volume of the dentate gyrus of the mutant was significantly smaller compared to the normal counterpart. This size reduction seemed to be dependent on apoptosis rather than due to a decrease in the rate of cell division. (C) 2009 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.",

keywords = "Repulsive axon guidance protein, Draxin, Knockout mouse, Hippocampus, Cell death, Dentate gyrus, DENTATE-GYRUS, CELL-PROLIFERATION, GRANULE CELLS, EXPRESSION, NEUROGENESIS, FOREBRAIN, MIGRATION, REELIN, GROWTH, DIFFERENTIATION",

author = "Sanbing Zhang and Yuhong Su and Yohei Shinmyo and Islam, {Shahidul M.} and {Bin Naser}, Iftekhar and Giasuddin Ahmed and Nobuaki Tamamaki and Hideaki Tanaka",

year = "2010",

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volume = "66",

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journal = "Neuroscience Research",

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T1 - Draxin, a repulsive axon guidance protein, is involved in hippocampal development

AU - Zhang, Sanbing

AU - Su, Yuhong

AU - Shinmyo, Yohei

AU - Islam, Shahidul M.

AU - Bin Naser, Iftekhar

AU - Ahmed, Giasuddin

AU - Tamamaki, Nobuaki

AU - Tanaka, Hideaki

PY - 2010/1

Y1 - 2010/1

N2 - The hippocampus plays an essential role in learning and memory and is one of the major sites implicated in neural diseases. The proper organization of the hippocampus during development is important for its function. We found that draxin, a repulsive axon guidance cue, was widely expressed in the developing hippocampus and draxin deficient mice possessed a smaller hippocampus, particularly in the anterior part of the structure. Quantification of this reduction revealed that the volume of the dentate gyrus of the mutant was significantly smaller compared to the normal counterpart. This size reduction seemed to be dependent on apoptosis rather than due to a decrease in the rate of cell division. (C) 2009 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

AB - The hippocampus plays an essential role in learning and memory and is one of the major sites implicated in neural diseases. The proper organization of the hippocampus during development is important for its function. We found that draxin, a repulsive axon guidance cue, was widely expressed in the developing hippocampus and draxin deficient mice possessed a smaller hippocampus, particularly in the anterior part of the structure. Quantification of this reduction revealed that the volume of the dentate gyrus of the mutant was significantly smaller compared to the normal counterpart. This size reduction seemed to be dependent on apoptosis rather than due to a decrease in the rate of cell division. (C) 2009 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

KW - Repulsive axon guidance protein

KW - Draxin

KW - Knockout mouse

KW - Hippocampus

KW - Cell death

KW - Dentate gyrus

KW - DENTATE-GYRUS

KW - CELL-PROLIFERATION

KW - GRANULE CELLS

KW - EXPRESSION

KW - NEUROGENESIS

KW - FOREBRAIN

KW - MIGRATION

KW - REELIN

KW - GROWTH

KW - DIFFERENTIATION

U2 - 10.1016/j.neures.2009.09.1710

DO - 10.1016/j.neures.2009.09.1710

M3 - Article

C2 - 19808066

SN - 0168-0102

VL - 66

SP - 53

EP - 61

JO - Neuroscience Research

JF - Neuroscience Research

IS - 1

ER -

Draxin, a repulsive axon guidance protein, is involved in hippocampal development

Abstract

Keywords

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