Draxin is involved in the proper development of the dI3 interneuron in chick spinal cord

Yuhong Su, Sanbing Zhang, Shahidul M. Islam, Yohei Shinmyo, Iftekhar Bin Naser, Giasuddin Ahmed, Hideaki Tanaka*

*Corresponding author for this work

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Generation of the appropriate types, numbers and distribution of neurons during the development of the nervous system requires the careful coordination of proliferation, differentiation, and patterning. In this work, we analyzed the roles of a repulsive axon guidance protein, draxin, on the development of chick spinal cord dI3 interneuron. draxin mRNA and/or protein were detected in the roof plate at first and then the boundary region between the ventricular and the mantle zones in chick spinal cord and dorsal basement membrane of the chick spinal cord. Overexpression of draxin caused the decreased and delayed migration of the dI3 interneuron, the reduction of progenitor cell proliferation, and abnormal localization of some ectopic progenitor-like cells in the mantle zone of the spinal cord. Our data reveal that draxin may be involved in the proper development of the dI3 interneuron in chick spinal cord. Developmental Dynamics 239:1654-1663, 2010. (C) 2010 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)1654-1663
Number of pages10
JournalDevelopmental Dynamics
Volume239
Issue number6
DOIs
Publication statusPublished - Jun 2010
Externally publishedYes

Keywords

  • draxin
  • dI3 interneuron
  • chick
  • spinal cord
  • proliferation
  • migration
  • NUCLEAR MIGRATION
  • GUIDANCE PROTEIN
  • ROOF PLATE
  • EXPRESSION
  • DORSAL
  • SPECIFICATION
  • BRAIN
  • CELLS
  • NEUROGENESIS
  • PATTERNS

Cite this

Su, Y., Zhang, S., Islam, S. M., Shinmyo, Y., Bin Naser, I., Ahmed, G., & Tanaka, H. (2010). Draxin is involved in the proper development of the dI3 interneuron in chick spinal cord. Developmental Dynamics, 239(6), 1654-1663. https://doi.org/10.1002/dvdy.22299