Drug-eluting stents are associated with similar cardiovascular outcomes when compared to bare metal stents in the setting of acute myocardial infarction

Tina L Pinto Slottow, Daniel H. Steinberg, Probal Roy, Aamir Javaid, Ashesh N. Buch, Teruo Okabe, Zhenyi Xue, Kimberly Smith, Rebecca Torguson, Augusto D. Pichard, Lowell F. Satler, William O. Suddath, Kenneth M. Kent, Ron Waksman*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    13 Citations (Scopus)

    Abstract

    Background: Recent randomized trials have demonstrated conflicting results regarding the use of drug-eluting stents (DESs) as compared to bare metal stents (BMSs) in primary percutaneous coronary intervention (PCI). We compared outcomes among patients presenting with acute ST-elevation myocardial infarction (STEMI) who received DES with those who received BMS. Methods: In-hospital, 30-day, 6-month, and 1-year outcomes of a cohort of 122 patients who underwent primary or facilitated PCI and received a BMS were compared to 122 propensity-matched patients who received a DES. Seventy-two patients received sirolimus-eluting stents, and 50 received paclitaxel-eluting stents. Results: Baseline demographics were similar among groups. One-, 6-, and 12-month outcomes, including reinfarction, death, stent thrombosis, and target vessel revascularization (TVR), were similar among groups. At 1 year, all-cause mortality was 13.3% in the BMS group and 9.2% in the DES group [P=not significant (ns)], recurrent MI was 5.3% in the BMS group vs. 4.4% in the DES group (P=ns), and TVR was 7% in the BMS group vs. 8.7% in the DES group (P=ns). Conclusions: Our data do not support the general use of DES in the setting of STEMI given similar cardiovascular outcomes among patients receiving BMS or DES, the need for long-term dual antiplatelet therapy with DES, and the possible repercussions of very late stent thrombosis.

    Original languageEnglish
    Pages (from-to)24-28
    Number of pages5
    JournalCardiovascular Revascularization Medicine
    Volume9
    Issue number1
    DOIs
    Publication statusPublished - Jan 2008

    Keywords

    • Acute myocardial infarction
    • Bare metal stents
    • Drug-eluting stents

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