Abstract
Acute single-dose response of drug-induced parkinsonism (DIP) to L-Dopa and apomorphine challenge was evaluated in a double-blind crossover study in 12 schizophrenic patients. There were two noteworthy negative findings. First, neither L-Dopa nor apomorphine produced significant improvements in DIP and second, no changes (neither improvement nor worsening) were found in patients' psychiatric status. Findings suggest that, for a stimulation dose reaching almost 90% of the responsive dose for idiopathic Parkinson's disease, no significant changes may reasonably be expected in the parkinsonism of schizophrenic patients treated with neuroleptic drugs.
Original language | English |
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Pages (from-to) | 439-443 |
Number of pages | 5 |
Journal | Clinical Neuropharmacology |
Volume | 19 |
Issue number | 5 |
Publication status | Published - 1996 |
Externally published | Yes |
Keywords
- Acute challenge
- Apomorphine
- Drug-induced parkinsonism
- L-Dopa
- Neuroleptic drugs
- Secondary parkinsonism