Drug-induced parkinsonism in schizophrenic patients: Motor response and psychiatric changes after acute challenge with L-Dopa and apomorphine

M. Merello*, S. Starkstein, G. Petracca, E. A. Cataneo, F. Manes, R. Leiguarda

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Acute single-dose response of drug-induced parkinsonism (DIP) to L-Dopa and apomorphine challenge was evaluated in a double-blind crossover study in 12 schizophrenic patients. There were two noteworthy negative findings. First, neither L-Dopa nor apomorphine produced significant improvements in DIP and second, no changes (neither improvement nor worsening) were found in patients' psychiatric status. Findings suggest that, for a stimulation dose reaching almost 90% of the responsive dose for idiopathic Parkinson's disease, no significant changes may reasonably be expected in the parkinsonism of schizophrenic patients treated with neuroleptic drugs.

Original languageEnglish
Pages (from-to)439-443
Number of pages5
JournalClinical Neuropharmacology
Volume19
Issue number5
Publication statusPublished - 1996
Externally publishedYes

Keywords

  • Acute challenge
  • Apomorphine
  • Drug-induced parkinsonism
  • L-Dopa
  • Neuroleptic drugs
  • Secondary parkinsonism

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