Dupuytren's Disease and exposure to vibration: systematic review and meta-analysis

Sylvain Mathieu*, Geraldine Naughton, Alexis Descatha, Martin Soubrier, Frédéric Dutheil

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    10 Citations (Scopus)


    Introduction: Dupuytren's Disease (DD) occurs frequently in the entire population. Several risk factors are well known, including diabetes, alcohol, and age. In this meta-analysis, we assessed the role of occupational vibration exposure in the risk of DD, an issue currently under debate.

    Methods: We searched PubMed, Google Scholar, and the Cochrane Library to find references up to June 2019. DD prevalence was calculated using meta-proportion analysis. Differences in characteristics between DD patients and controls were expressed as standardized mean differences using the inverse of variance method or percentages using also meta-proportion analysis. We performed meta-regression analyses to assess the effects of alcohol, smoking, age, and sex on the DD incidence for the patients with DD that were exposed to vibrations.

    Results: We included 9 studies, comprising a total of 60,570 patients, including 1,804 DD patients. Prevalence of DD was 9.8% (95%CI: 5.9–14.4%). Compared with controls, patients with DD were older, more diabetic, more smokers and with a higher consumption of alcohol. Meta-analysis of the nine longitudinal studies comparing DD occurrence between patients exposed to vibration (626 of 6825) or not (1220 of 52,502) revealed a significantly increased DD incidence among patients with vibration exposure compared with controls (OR = 2.87; 95%CI: 1.41–5.84). In metaregression we found no significant influence of all parameters on DD.

    Conclusion: Age and environmental factors had no effect on DD prevalence among patients exposed to vibrations, despite a 10% prevalence in this group. Using vibration tools at work should be recognized as an important risk factor of developing DD.

    Original languageEnglish
    Pages (from-to)203-207
    Number of pages5
    JournalJoint Bone Spine
    Issue number3
    Publication statusPublished - May 2020


    • Dupuytren disease
    • Meta-analysis
    • Vibration exposure
    • Work


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