Dynamic vascular changes following intravenous antibiotics in patients with cystic fibrosis

James H. Hull*, Rachel Garrod, Timothy B. Ho, Ronald K. Knight, John R. Cockcroft, Dennis J. Shale, Charlotte E. Bolton

*Corresponding author for this work

    Research output: Contribution to journalArticle

    5 Citations (Scopus)

    Abstract

    Background: Adults with cystic fibrosis (CF) have altered large artery haemodynamics which is associated with a persisting systemic inflammatory state. We hypothesized that a short-term intervention favorably influencing the inflammatory status may modify their haemodynamic state. Methods: Adult patients with CF were studied immediately preceding and following 2. weeks of intravenous antibiotics. Large artery haemodynamics, principally heart rate-adjusted augmentation index (AIx) were obtained. Blood pressure (BP), spirometry and CRP were also measured. Results: Complete data was available for 15 patients; mean (SD) age 28 (6)years. CRP was reduced while FEV1% predicted improved. Following treatment AIx was lower: 10.9 (10.9)% to 8.1 (10.9)% (p<0.05) while BP was similar and a trend toward lower heart rate (p=0.06). Change in AIx was related to baseline FEV1% predicted (r=0.77) and BMI (r=0.71) (both P<0.01). Conclusion: The abnormal central haemodynamics evident in adults with CF is modulated with a short intervention of intravenous antibiotics.

    Original languageEnglish
    Pages (from-to)125-129
    Number of pages5
    JournalJournal of Cystic Fibrosis
    Volume12
    Issue number2
    DOIs
    Publication statusPublished - Mar 2013

    Keywords

    • Arterial
    • Blood pressure
    • Cystic fibrosis
    • Inflammation
    • Stiffness
    • Vascular

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    Hull, J. H., Garrod, R., Ho, T. B., Knight, R. K., Cockcroft, J. R., Shale, D. J., & Bolton, C. E. (2013). Dynamic vascular changes following intravenous antibiotics in patients with cystic fibrosis. Journal of Cystic Fibrosis, 12(2), 125-129. https://doi.org/10.1016/j.jcf.2012.07.004