Dynamic vascular changes following intravenous antibiotics in patients with cystic fibrosis

James H. Hull; Rachel Garrod; Timothy B. Ho; Ronald K. Knight; John R. Cockcroft; Dennis J. Shale; Charlotte E. Bolton

doi:10.1016/j.jcf.2012.07.004

Dynamic vascular changes following intravenous antibiotics in patients with cystic fibrosis

James H. Hull^*, Rachel Garrod, Timothy B. Ho, Ronald K. Knight, John R. Cockcroft, Dennis J. Shale, Charlotte E. Bolton

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Background: Adults with cystic fibrosis (CF) have altered large artery haemodynamics which is associated with a persisting systemic inflammatory state. We hypothesized that a short-term intervention favorably influencing the inflammatory status may modify their haemodynamic state. Methods: Adult patients with CF were studied immediately preceding and following 2. weeks of intravenous antibiotics. Large artery haemodynamics, principally heart rate-adjusted augmentation index (AIx) were obtained. Blood pressure (BP), spirometry and CRP were also measured. Results: Complete data was available for 15 patients; mean (SD) age 28 (6)years. CRP was reduced while FEV₁% predicted improved. Following treatment AIx was lower: 10.9 (10.9)% to 8.1 (10.9)% (p<0.05) while BP was similar and a trend toward lower heart rate (p=0.06). Change in AIx was related to baseline FEV₁% predicted (r=0.77) and BMI (r=0.71) (both P<0.01). Conclusion: The abnormal central haemodynamics evident in adults with CF is modulated with a short intervention of intravenous antibiotics.

Original language	English
Pages (from-to)	125-129
Number of pages	5
Journal	Journal of Cystic Fibrosis
Volume	12
Issue number	2
DOIs	https://doi.org/10.1016/j.jcf.2012.07.004
Publication status	Published - Mar 2013

Keywords

Arterial
Blood pressure
Cystic fibrosis
Inflammation
Stiffness
Vascular

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10.1016/j.jcf.2012.07.004

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title = "Dynamic vascular changes following intravenous antibiotics in patients with cystic fibrosis",

abstract = "Background: Adults with cystic fibrosis (CF) have altered large artery haemodynamics which is associated with a persisting systemic inflammatory state. We hypothesized that a short-term intervention favorably influencing the inflammatory status may modify their haemodynamic state. Methods: Adult patients with CF were studied immediately preceding and following 2. weeks of intravenous antibiotics. Large artery haemodynamics, principally heart rate-adjusted augmentation index (AIx) were obtained. Blood pressure (BP), spirometry and CRP were also measured. Results: Complete data was available for 15 patients; mean (SD) age 28 (6)years. CRP was reduced while FEV1% predicted improved. Following treatment AIx was lower: 10.9 (10.9)% to 8.1 (10.9)% (p<0.05) while BP was similar and a trend toward lower heart rate (p=0.06). Change in AIx was related to baseline FEV1% predicted (r=0.77) and BMI (r=0.71) (both P<0.01). Conclusion: The abnormal central haemodynamics evident in adults with CF is modulated with a short intervention of intravenous antibiotics.",

keywords = "Arterial, Blood pressure, Cystic fibrosis, Inflammation, Stiffness, Vascular",

author = "Hull, {James H.} and Rachel Garrod and Ho, {Timothy B.} and Knight, {Ronald K.} and Cockcroft, {John R.} and Shale, {Dennis J.} and Bolton, {Charlotte E.}",

year = "2013",

month = mar,

doi = "10.1016/j.jcf.2012.07.004",

language = "English",

volume = "12",

pages = "125--129",

journal = "Journal of Cystic Fibrosis",

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AU - Hull, James H.

AU - Garrod, Rachel

AU - Ho, Timothy B.

AU - Knight, Ronald K.

AU - Cockcroft, John R.

AU - Shale, Dennis J.

AU - Bolton, Charlotte E.

PY - 2013/3

Y1 - 2013/3

N2 - Background: Adults with cystic fibrosis (CF) have altered large artery haemodynamics which is associated with a persisting systemic inflammatory state. We hypothesized that a short-term intervention favorably influencing the inflammatory status may modify their haemodynamic state. Methods: Adult patients with CF were studied immediately preceding and following 2. weeks of intravenous antibiotics. Large artery haemodynamics, principally heart rate-adjusted augmentation index (AIx) were obtained. Blood pressure (BP), spirometry and CRP were also measured. Results: Complete data was available for 15 patients; mean (SD) age 28 (6)years. CRP was reduced while FEV1% predicted improved. Following treatment AIx was lower: 10.9 (10.9)% to 8.1 (10.9)% (p<0.05) while BP was similar and a trend toward lower heart rate (p=0.06). Change in AIx was related to baseline FEV1% predicted (r=0.77) and BMI (r=0.71) (both P<0.01). Conclusion: The abnormal central haemodynamics evident in adults with CF is modulated with a short intervention of intravenous antibiotics.

AB - Background: Adults with cystic fibrosis (CF) have altered large artery haemodynamics which is associated with a persisting systemic inflammatory state. We hypothesized that a short-term intervention favorably influencing the inflammatory status may modify their haemodynamic state. Methods: Adult patients with CF were studied immediately preceding and following 2. weeks of intravenous antibiotics. Large artery haemodynamics, principally heart rate-adjusted augmentation index (AIx) were obtained. Blood pressure (BP), spirometry and CRP were also measured. Results: Complete data was available for 15 patients; mean (SD) age 28 (6)years. CRP was reduced while FEV1% predicted improved. Following treatment AIx was lower: 10.9 (10.9)% to 8.1 (10.9)% (p<0.05) while BP was similar and a trend toward lower heart rate (p=0.06). Change in AIx was related to baseline FEV1% predicted (r=0.77) and BMI (r=0.71) (both P<0.01). Conclusion: The abnormal central haemodynamics evident in adults with CF is modulated with a short intervention of intravenous antibiotics.

KW - Arterial

KW - Blood pressure

KW - Cystic fibrosis

KW - Inflammation

KW - Stiffness

KW - Vascular

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Dynamic vascular changes following intravenous antibiotics in patients with cystic fibrosis

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