Dynamics of HCV RNA levels during acute hepatitis C virus infection

Behzad Hajarizadeh*, Jason Grebely, Tanya Applegate, Gail V. Matthews, Janaki Amin, Kathy Petoumenos, Margaret Hellard, William Rawlinson, Andrew Lloyd, John Kaldor, Gregory J. Dore

*Corresponding author for this work

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Understanding viral dynamics during acute hepatitis C virus (HCV) infection can provide important insights into immunopathogenesis and guide early treatment. The aim of this study was to investigate the dynamics of HCV RNA and alanine transaminase (ALT) levels during recent HCV infection in the Australian Trial in Acute Hepatitis C (ATAHC). ATAHC was a prospective study of the natural history of recently acquired HCV infection. Longitudinal HCV RNA and ALT levels were compared among individuals with persistent infection and spontaneous clearance. Among those with HCV persistence (n = 104) and HCV clearance (n = 30), median HCV RNA (5.2 vs. 4.1 log IU/ml, respectively) and ALT levels (779 vs. 1,765 IU/L, respectively) were high during month two following infection, and then declined during months three and four in both groups. Among those with HCV persistence, median HCV RNA was 2.9 log IU/ml during months four, increased to 5.5 log IU/ml during month five, and remained subsequently relatively stable. Among those with HCV clearance, median HCV RNA was undetectable by month five. Median HCV RNA levels were comparable between individuals with HCV persistence and HCV clearance during month three following infection (3.2 vs. 3.5 log IU/ml, respectively; P = 0.935), but markedly different during month five (5.5 vs. 1.0 log IU/ml, respectively; P<0.001). In conclusion, dynamics of HCV RNA levels in those with HCV clearance and HCV persistence diverged between months three and five following infection, with the latter time-point being potentially useful for commencing early treatment.

Original languageEnglish
Pages (from-to)1722-1729
Number of pages8
JournalJournal of Medical Virology
Volume86
Issue number10
DOIs
Publication statusPublished - Oct 2014
Externally publishedYes

Keywords

  • Alanine transaminase
  • Chronic
  • Persistent infection
  • Spontaneous clearance
  • Viral load

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