e-Science: Relieving bottlenecks in large-scale genome analyses

Tracy Craddock, Colin R. Harwood*, Jennifer Hallinan, Anil Wipat

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


The development of affordable, high-throughput sequencing technology has led to a flood of publicly available bacterial genome-sequence data. The availability of multiple genome sequences presents both an opportunity and a challenge for microbiologists, and new computational approaches are needed to extract the knowledge that is required to address specific biological problems and to analyse genomic data. The field of e-Science is maturing, and Grid-based technologies can help address this challenge.

Original languageEnglish
Pages (from-to)948-954
Number of pages7
JournalNature Reviews Microbiology
Issue number12
Publication statusPublished - 2008
Externally publishedYes


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