Early and delayed evaluation of solid tumours with 64Cu-ATSM PET/CT: a pilot study on semiquantitative and computer-aided fractal geometry analysis

Egesta Lopci; Fabio Grizzi; Carlo Russo; Luca Toschi; Ilaria Grassi; Gianfranco Cicoria; Filippo Lodi; Sandro Mattioli; Stefano Fanti

doi:10.1097/MNM.0000000000000656

Early and delayed evaluation of solid tumours with ⁶⁴Cu-ATSM PET/CT: a pilot study on semiquantitative and computer-aided fractal geometry analysis

Egesta Lopci^*, Fabio Grizzi, Carlo Russo, Luca Toschi, Ilaria Grassi, Gianfranco Cicoria, Filippo Lodi, Sandro Mattioli, Stefano Fanti

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Objective: The aim of this study was to analyse early and delayed acquisition on copper-64 diacetyl-bisN4-methylthiosemicarbazone (⁶⁴Cu-ATSM) PET/CT in a small cohort of patients by comparing semiquantitative and computer-aided fractal geometry analyses. Patients and methods: Five cancer patients, including non-small-cell lung cancer and head and neck cancer, were investigated with ⁶⁴Cu-ATSM PET/CT. Participants received an intravenous injection of ⁶⁴Cu-ATSM according to body size and were imaged 60 min (early) and 16 h (delayed) later on hybrid PET/CT. Reconstructed images were visualized on advanced workstations for the definition of semiquantitative parameters: standardized uptake value (SUV)_max, SUV_ratio-to-muscle, SUV_mean, hypoxic volume (HV) and hypoxic burden (HB=HV×SUV_mean). DICOM data retrieved from both scans were analysed using an ad-hoc computer program to determine the mean intensity value, SD, relative dispersion, three-dimensional histogram fractal dimension and three-dimensional fractal dimension. Results: All tumour lesions showed increased uptake of ⁶⁴Cu-ATSM at early evaluation, with a median SUV_ratio-to-muscle of 4.42 (range: 1.58-5.62), a median SUV_max of 5.3 (range: 1.9-7.3), a median SUV_mean of 2.8 (range: 1.5-3.9), a median HV of 41.6 cm 3 (range: 2.8-453.7) and a median HB of 161.5 cm 3 (range: 4.4-1112.5). All semiquantitative data obtained at 1 h were consistent with the parameters obtained on delayed imaging (P>0.05). A borderline statistically significant difference was found only for SUV_max of the muscle (P=0.045). Fractal geometry analysis on DICOM images showed that all parameters at early imaging showed no statistically significant difference with late acquisition (P>0.05). Conclusion: Our findings support the consistency of ⁶⁴Cu-ATSM PET/CT images obtained at early and delayed acquisition for the assessment of tumour lesions.

Original language	English
Pages (from-to)	340-346
Number of pages	7
Journal	Nuclear Medicine Communications
Volume	38
Issue number	4
DOIs	https://doi.org/10.1097/MNM.0000000000000656
Publication status	Published - Apr 2017
Externally published	Yes

Keywords

copper-64 diacetyl-bis N 4-methylthiosemicarbazone
delayed imaging
early imaging
fractals
hypoxia imaging
image analysis
positron emission tomography/computed tomography

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10.1097/MNM.0000000000000656

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@article{497553177f2c40d997d72cddd28f0e7d,

title = "Early and delayed evaluation of solid tumours with 64Cu-ATSM PET/CT: a pilot study on semiquantitative and computer-aided fractal geometry analysis",

abstract = "Objective: The aim of this study was to analyse early and delayed acquisition on copper-64 diacetyl-bisN4-methylthiosemicarbazone (64Cu-ATSM) PET/CT in a small cohort of patients by comparing semiquantitative and computer-aided fractal geometry analyses. Patients and methods: Five cancer patients, including non-small-cell lung cancer and head and neck cancer, were investigated with 64Cu-ATSM PET/CT. Participants received an intravenous injection of 64Cu-ATSM according to body size and were imaged 60 min (early) and 16 h (delayed) later on hybrid PET/CT. Reconstructed images were visualized on advanced workstations for the definition of semiquantitative parameters: standardized uptake value (SUV)max, SUVratio-to-muscle, SUVmean, hypoxic volume (HV) and hypoxic burden (HB=HV×SUVmean). DICOM data retrieved from both scans were analysed using an ad-hoc computer program to determine the mean intensity value, SD, relative dispersion, three-dimensional histogram fractal dimension and three-dimensional fractal dimension. Results: All tumour lesions showed increased uptake of 64Cu-ATSM at early evaluation, with a median SUVratio-to-muscle of 4.42 (range: 1.58-5.62), a median SUVmax of 5.3 (range: 1.9-7.3), a median SUVmean of 2.8 (range: 1.5-3.9), a median HV of 41.6 cm 3 (range: 2.8-453.7) and a median HB of 161.5 cm 3 (range: 4.4-1112.5). All semiquantitative data obtained at 1 h were consistent with the parameters obtained on delayed imaging (P>0.05). A borderline statistically significant difference was found only for SUVmax of the muscle (P=0.045). Fractal geometry analysis on DICOM images showed that all parameters at early imaging showed no statistically significant difference with late acquisition (P>0.05). Conclusion: Our findings support the consistency of 64Cu-ATSM PET/CT images obtained at early and delayed acquisition for the assessment of tumour lesions.",

keywords = "copper-64 diacetyl-bis N 4-methylthiosemicarbazone, delayed imaging, early imaging, fractals, hypoxia imaging, image analysis, positron emission tomography/computed tomography",

author = "Egesta Lopci and Fabio Grizzi and Carlo Russo and Luca Toschi and Ilaria Grassi and Gianfranco Cicoria and Filippo Lodi and Sandro Mattioli and Stefano Fanti",

year = "2017",

month = apr,

doi = "10.1097/MNM.0000000000000656",

language = "English",

volume = "38",

pages = "340--346",

journal = "Nuclear Medicine Communications",

issn = "0143-3636",

publisher = "Wolters Kluwer Health",

number = "4",

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TY - JOUR

T1 - Early and delayed evaluation of solid tumours with 64Cu-ATSM PET/CT

T2 - a pilot study on semiquantitative and computer-aided fractal geometry analysis

AU - Lopci, Egesta

AU - Grizzi, Fabio

AU - Russo, Carlo

AU - Toschi, Luca

AU - Grassi, Ilaria

AU - Cicoria, Gianfranco

AU - Lodi, Filippo

AU - Mattioli, Sandro

AU - Fanti, Stefano

PY - 2017/4

Y1 - 2017/4

N2 - Objective: The aim of this study was to analyse early and delayed acquisition on copper-64 diacetyl-bisN4-methylthiosemicarbazone (64Cu-ATSM) PET/CT in a small cohort of patients by comparing semiquantitative and computer-aided fractal geometry analyses. Patients and methods: Five cancer patients, including non-small-cell lung cancer and head and neck cancer, were investigated with 64Cu-ATSM PET/CT. Participants received an intravenous injection of 64Cu-ATSM according to body size and were imaged 60 min (early) and 16 h (delayed) later on hybrid PET/CT. Reconstructed images were visualized on advanced workstations for the definition of semiquantitative parameters: standardized uptake value (SUV)max, SUVratio-to-muscle, SUVmean, hypoxic volume (HV) and hypoxic burden (HB=HV×SUVmean). DICOM data retrieved from both scans were analysed using an ad-hoc computer program to determine the mean intensity value, SD, relative dispersion, three-dimensional histogram fractal dimension and three-dimensional fractal dimension. Results: All tumour lesions showed increased uptake of 64Cu-ATSM at early evaluation, with a median SUVratio-to-muscle of 4.42 (range: 1.58-5.62), a median SUVmax of 5.3 (range: 1.9-7.3), a median SUVmean of 2.8 (range: 1.5-3.9), a median HV of 41.6 cm 3 (range: 2.8-453.7) and a median HB of 161.5 cm 3 (range: 4.4-1112.5). All semiquantitative data obtained at 1 h were consistent with the parameters obtained on delayed imaging (P>0.05). A borderline statistically significant difference was found only for SUVmax of the muscle (P=0.045). Fractal geometry analysis on DICOM images showed that all parameters at early imaging showed no statistically significant difference with late acquisition (P>0.05). Conclusion: Our findings support the consistency of 64Cu-ATSM PET/CT images obtained at early and delayed acquisition for the assessment of tumour lesions.

AB - Objective: The aim of this study was to analyse early and delayed acquisition on copper-64 diacetyl-bisN4-methylthiosemicarbazone (64Cu-ATSM) PET/CT in a small cohort of patients by comparing semiquantitative and computer-aided fractal geometry analyses. Patients and methods: Five cancer patients, including non-small-cell lung cancer and head and neck cancer, were investigated with 64Cu-ATSM PET/CT. Participants received an intravenous injection of 64Cu-ATSM according to body size and were imaged 60 min (early) and 16 h (delayed) later on hybrid PET/CT. Reconstructed images were visualized on advanced workstations for the definition of semiquantitative parameters: standardized uptake value (SUV)max, SUVratio-to-muscle, SUVmean, hypoxic volume (HV) and hypoxic burden (HB=HV×SUVmean). DICOM data retrieved from both scans were analysed using an ad-hoc computer program to determine the mean intensity value, SD, relative dispersion, three-dimensional histogram fractal dimension and three-dimensional fractal dimension. Results: All tumour lesions showed increased uptake of 64Cu-ATSM at early evaluation, with a median SUVratio-to-muscle of 4.42 (range: 1.58-5.62), a median SUVmax of 5.3 (range: 1.9-7.3), a median SUVmean of 2.8 (range: 1.5-3.9), a median HV of 41.6 cm 3 (range: 2.8-453.7) and a median HB of 161.5 cm 3 (range: 4.4-1112.5). All semiquantitative data obtained at 1 h were consistent with the parameters obtained on delayed imaging (P>0.05). A borderline statistically significant difference was found only for SUVmax of the muscle (P=0.045). Fractal geometry analysis on DICOM images showed that all parameters at early imaging showed no statistically significant difference with late acquisition (P>0.05). Conclusion: Our findings support the consistency of 64Cu-ATSM PET/CT images obtained at early and delayed acquisition for the assessment of tumour lesions.

KW - copper-64 diacetyl-bis N 4-methylthiosemicarbazone

KW - delayed imaging

KW - early imaging

KW - fractals

KW - hypoxia imaging

KW - image analysis

KW - positron emission tomography/computed tomography

UR - https://www.scopus.com/pages/publications/85014548193

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DO - 10.1097/MNM.0000000000000656

M3 - Article

C2 - 28263239

AN - SCOPUS:85014548193

SN - 0143-3636

VL - 38

SP - 340

EP - 346

JO - Nuclear Medicine Communications

JF - Nuclear Medicine Communications

IS - 4

ER -

Early and delayed evaluation of solid tumours with ⁶⁴Cu-ATSM PET/CT: a pilot study on semiquantitative and computer-aided fractal geometry analysis

Abstract

Keywords

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