TY - JOUR
T1 - Early and late childhood telomere length predict subclinical atherosclerosis at age 14 yrs.
T2 - The CardioCAPS study
AU - Barraclough, Jennifer Y.
AU - Skilton, Michael R.
AU - Garden, Frances L.
AU - Toelle, Brett G.
AU - Marks, Guy B.
AU - Celermajer, David S.
PY - 2019/3/1
Y1 - 2019/3/1
N2 - Introduction: Carotid Intima Media Thickness (CIMT) is a marker of subclinical atherosclerosis, associated with cardiovascular risk in adults. Telomere length (TL) is a marker of cellular ageing. We sought to determine whether telomere length in early childhood and/or at 14-years is associated with CIMT in adolescence, in a community-based cohort study. Methods: 118 children had TL measured at mean age 3.6-years and 165 children had TL and CIMT, measured at 14-years, from the community-based Childhood Asthma Prevention Study. Results: TL in early childhood was significantly inversely associated with CIMT at 14 years, p = 0.04. TL in teenage life was also significantly inversely associated with CIMT at 14 years, p = 0.03. This latter association was no longer significant, however, after adjusting for early life TL. Conclusion: TL measured in early childhood and adolescence is significantly associated with CIMT at 14-years, suggesting that telomere length is a biological marker or even early determinant of late cardiovascular risk.
AB - Introduction: Carotid Intima Media Thickness (CIMT) is a marker of subclinical atherosclerosis, associated with cardiovascular risk in adults. Telomere length (TL) is a marker of cellular ageing. We sought to determine whether telomere length in early childhood and/or at 14-years is associated with CIMT in adolescence, in a community-based cohort study. Methods: 118 children had TL measured at mean age 3.6-years and 165 children had TL and CIMT, measured at 14-years, from the community-based Childhood Asthma Prevention Study. Results: TL in early childhood was significantly inversely associated with CIMT at 14 years, p = 0.04. TL in teenage life was also significantly inversely associated with CIMT at 14 years, p = 0.03. This latter association was no longer significant, however, after adjusting for early life TL. Conclusion: TL measured in early childhood and adolescence is significantly associated with CIMT at 14-years, suggesting that telomere length is a biological marker or even early determinant of late cardiovascular risk.
KW - Carotid intima-media thickness
KW - Adolescence
KW - Ageing
KW - Telomeres
UR - http://www.scopus.com/inward/record.url?scp=85059142913&partnerID=8YFLogxK
U2 - 10.1016/j.ijcard.2018.12.065
DO - 10.1016/j.ijcard.2018.12.065
M3 - Article
C2 - 30595356
SN - 0167-5273
VL - 278
SP - 250
EP - 253
JO - International Journal of Cardiology
JF - International Journal of Cardiology
ER -