Early detection of intentional harm in the human amygdala

Eugenia Hesse, Ezequiel Mikulan, Jean Decety, Mariano Sigman, María Del Carmen Garcia, Walter Silva, Carlos Ciraolo, Esteban Vaucheret, Fabricio Baglivo, David Huepe, Vladimir Lopez, Facundo Manes, Tristan A. Bekinschtein, Agustin Ibanez*

*Corresponding author for this work

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

A decisive element of moral cognition is the detection of harm and its assessment as intentional or unintentional. Moral cognition engages brain networks supporting mentalizing, intentionality, empathic concern and evaluation. These networks rely on the amygdala as a critical hub, likely through frontotemporal connections indexing stimulus salience. We assessed inferences about perceived harm using a paradigm validated through functional magnetic resonance imaging, eye-tracking and electroencephalogram recordings. During the task, we measured local field potentials in three patients with depth electrodes (n = 115) placed in the amygdala and in several frontal, temporal, and parietal locations. Direct electrophysiological recordings demonstrate that intentional harm induces early activity in the amygdala (5 200 ms), which-in turn-predicts intention attribution. The amygdala was the only site that systematically discriminated between critical conditions and predicted their classification of events as intentional. Moreover, connectivity analysis showed that intentional harm induced stronger frontotemporal information sharing at early stages. Results support the 'many roads' view of the amygdala and highlight its role in the rapid encoding of intention and salience-critical components of mentalizing and moral evaluation.

Original languageEnglish
Pages (from-to)54-61
Number of pages8
JournalBrain
Volume139
Issue number1
DOIs
Publication statusPublished - 1 Jan 2016
Externally publishedYes

Keywords

  • Amygdala
  • Intentional harm
  • Intracranial recordings
  • Moral cognition

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