Early detection of memory impairment in Alzheimer's disease: A neurocognitive perspective on assessment

Georgia Lowndes*, Greg Savage

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    33 Citations (Scopus)

    Abstract

    We propose that the earliest neuropsychological detection of Alzheimer's disease (AD) can be informed by current views about the neuropathogenesis of AD and cognitive models of memory and its neurobiological substrates. The primary impairment in early AD is encoding/consolidation, resulting from medial temporal lobe (MTL) pathology. On theoretical and empirical grounds, paired associate learning (PAL) appears to be the ideal paradigm for detecting MTL dysfunction in early AD. It has not been embraced as a test of choice, however, and this critical review discusses why the paradigm may have not fulfilled its potential. We suggest that a new PAL variant, 'associate-recognition', may prove to be clinically efficacious.

    Original languageEnglish
    Pages (from-to)193-202
    Number of pages10
    JournalNeuropsychology Review
    Volume17
    Issue number3
    DOIs
    Publication statusPublished - Sep 2007

    Keywords

    • Alzheimer's disease
    • Associate learning
    • Dementia
    • Memory
    • Neuropsychology
    • Recall
    • Recognition

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