Early diagnosis of disease using microbead array technology: A review

Sanam Foroutan Parsa, Atieh Vafajoo, Azin Rostami, Reza Salarian, Mohammad Rabiee, Navid Rabiee, Ghazal Rabiee, Mohammadreza Tahriri, Amir Yadegari, Daryoosh Vashaee, Lobat Tayebi, Michael R. Hamblin*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

33 Citations (Scopus)

Abstract

Early diagnosis of diseases (before they become advanced and incurable) is essential to reduce morbidity and mortality rates. With the advent of novel technologies in clinical laboratory diagnosis, microbead-based arrays have come to be recognized as an efficient approach, that demonstrates useful advantages over traditional assay methods for multiple disease-related biomarkers. Multiplexed microbead assays provide a robust, rapid, specific, and cost-effective approach for high-throughput and simultaneous screening of many different targets. Biomolecular binding interactions occur after applying a biological sample (such as blood plasma, saliva, cerebrospinal fluid etc.) containing the target analyte(s) to a set of microbeads with different ligand-specificities that have been coded in planar or suspension arrays. The ligand-receptor binding activity is tracked by optical signals generated by means of flow cytometry analysis in the case of suspension arrays, or by image processing devices in the case of planar arrays. In this review paper, we discuss diagnosis of cancer, neurological and infectious diseases by using optically-encoded microbead-based arrays (both multiplexed and single-analyte assays) as a reliable tool for detection and quantification of various analytes.

Original languageEnglish
Pages (from-to)1-17
Number of pages17
JournalAnalytica Chimica Acta
Volume1032
DOIs
Publication statusPublished - 22 Nov 2018
Externally publishedYes

Keywords

  • Biomarker
  • Cancer
  • Early diagnosis
  • Infectious disease
  • Microbead array applications
  • Multiplexing
  • Neurological disease

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