Early human Papilloma virus (HPV) Oncogenic influences in breast cancer

Christopher Ngan, James S. Lawson*, Rosemary Clay, Warick Delprado, Noel J. Whitaker, Wendy K. Glenn

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)
5 Downloads (Pure)

Abstract

Background: Human papilloma viruses (HPVs) may act early in breast oncogenesis (“hit-and-run” phenomena). Methods: The authors used immunohistochemistry for the identification of HPV E7 oncogenic protein expression in 32 sets of benign and subsequent breast cancer specimens from the same Australian patients. Results: HPV E7 oncoprotein was clearly expressed in the nuclei of 23 (72%) of the 32 benign specimens and 20 (62.5%) of the subsequent 32 breast cancer specimens in the same patients. There was no HPV E7 protein expression in seven (30%) of the 23 breast cancer specimens that had prior HPV E7 protein-positive benign breast biopsies in the same patients. Conclusions: This observation suggests that HPV oncogenic influences occur early in some breast cancers. This finding confirms the previous observations. This early influence of HPVs may be the reason why there is no increase in the prevalence of HPV-associated breast cancer in immunocompromised patients as compared to HPV-associated cervical cancer.

Original languageEnglish
Pages (from-to)93-97
Number of pages5
JournalBreast Cancer: Basic and Clinical Research
Volume2015
Issue number9
DOIs
Publication statusPublished - 10 Dec 2015
Externally publishedYes

Bibliographical note

Copyright the Authors, publisher and licensee Libertas Academica Limited. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • Benign breast
  • Breast cancer
  • Cervimax
  • HPV E7 protein
  • Human papilloma virus (HPV)
  • Immunohistochemistry
  • Normal breast
  • PCR

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