Early human Papilloma virus (HPV) Oncogenic influences in breast cancer

Christopher Ngan; James S. Lawson; Rosemary Clay; Warick Delprado; Noel J. Whitaker; Wendy K. Glenn

doi:10.4137/BCBCR.S35692

Early human Papilloma virus (HPV) Oncogenic influences in breast cancer

Christopher Ngan, James S. Lawson^*, Rosemary Clay, Warick Delprado, Noel J. Whitaker, Wendy K. Glenn

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Background: Human papilloma viruses (HPVs) may act early in breast oncogenesis (“hit-and-run” phenomena). Methods: The authors used immunohistochemistry for the identification of HPV E7 oncogenic protein expression in 32 sets of benign and subsequent breast cancer specimens from the same Australian patients. Results: HPV E7 oncoprotein was clearly expressed in the nuclei of 23 (72%) of the 32 benign specimens and 20 (62.5%) of the subsequent 32 breast cancer specimens in the same patients. There was no HPV E7 protein expression in seven (30%) of the 23 breast cancer specimens that had prior HPV E7 protein-positive benign breast biopsies in the same patients. Conclusions: This observation suggests that HPV oncogenic influences occur early in some breast cancers. This finding confirms the previous observations. This early influence of HPVs may be the reason why there is no increase in the prevalence of HPV-associated breast cancer in immunocompromised patients as compared to HPV-associated cervical cancer.

Original language	English
Pages (from-to)	93-97
Number of pages	5
Journal	Breast Cancer: Basic and Clinical Research
Volume	2015
Issue number	9
DOIs	https://doi.org/10.4137/BCBCR.S35692
Publication status	Published - 10 Dec 2015
Externally published	Yes

Bibliographical note

Copyright the Authors, publisher and licensee Libertas Academica Limited. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

Benign breast
Breast cancer
Cervimax
HPV E7 protein
Human papilloma virus (HPV)
Immunohistochemistry
Normal breast
PCR

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10.4137/BCBCR.S35692

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title = "Early human Papilloma virus (HPV) Oncogenic influences in breast cancer",

abstract = "Background: Human papilloma viruses (HPVs) may act early in breast oncogenesis (“hit-and-run” phenomena). Methods: The authors used immunohistochemistry for the identification of HPV E7 oncogenic protein expression in 32 sets of benign and subsequent breast cancer specimens from the same Australian patients. Results: HPV E7 oncoprotein was clearly expressed in the nuclei of 23 (72\%) of the 32 benign specimens and 20 (62.5\%) of the subsequent 32 breast cancer specimens in the same patients. There was no HPV E7 protein expression in seven (30\%) of the 23 breast cancer specimens that had prior HPV E7 protein-positive benign breast biopsies in the same patients. Conclusions: This observation suggests that HPV oncogenic influences occur early in some breast cancers. This finding confirms the previous observations. This early influence of HPVs may be the reason why there is no increase in the prevalence of HPV-associated breast cancer in immunocompromised patients as compared to HPV-associated cervical cancer.",

keywords = "Benign breast, Breast cancer, Cervimax, HPV E7 protein, Human papilloma virus (HPV), Immunohistochemistry, Normal breast, PCR",

author = "Christopher Ngan and Lawson, \{James S.\} and Rosemary Clay and Warick Delprado and Whitaker, \{Noel J.\} and Glenn, \{Wendy K.\}",

note = "Copyright the Authors, publisher and licensee Libertas Academica Limited. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

year = "2015",

month = dec,

day = "10",

doi = "10.4137/BCBCR.S35692",

language = "English",

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T1 - Early human Papilloma virus (HPV) Oncogenic influences in breast cancer

AU - Ngan, Christopher

AU - Lawson, James S.

AU - Clay, Rosemary

AU - Delprado, Warick

AU - Whitaker, Noel J.

AU - Glenn, Wendy K.

N1 - Copyright the Authors, publisher and licensee Libertas Academica Limited. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2015/12/10

Y1 - 2015/12/10

N2 - Background: Human papilloma viruses (HPVs) may act early in breast oncogenesis (“hit-and-run” phenomena). Methods: The authors used immunohistochemistry for the identification of HPV E7 oncogenic protein expression in 32 sets of benign and subsequent breast cancer specimens from the same Australian patients. Results: HPV E7 oncoprotein was clearly expressed in the nuclei of 23 (72%) of the 32 benign specimens and 20 (62.5%) of the subsequent 32 breast cancer specimens in the same patients. There was no HPV E7 protein expression in seven (30%) of the 23 breast cancer specimens that had prior HPV E7 protein-positive benign breast biopsies in the same patients. Conclusions: This observation suggests that HPV oncogenic influences occur early in some breast cancers. This finding confirms the previous observations. This early influence of HPVs may be the reason why there is no increase in the prevalence of HPV-associated breast cancer in immunocompromised patients as compared to HPV-associated cervical cancer.

AB - Background: Human papilloma viruses (HPVs) may act early in breast oncogenesis (“hit-and-run” phenomena). Methods: The authors used immunohistochemistry for the identification of HPV E7 oncogenic protein expression in 32 sets of benign and subsequent breast cancer specimens from the same Australian patients. Results: HPV E7 oncoprotein was clearly expressed in the nuclei of 23 (72%) of the 32 benign specimens and 20 (62.5%) of the subsequent 32 breast cancer specimens in the same patients. There was no HPV E7 protein expression in seven (30%) of the 23 breast cancer specimens that had prior HPV E7 protein-positive benign breast biopsies in the same patients. Conclusions: This observation suggests that HPV oncogenic influences occur early in some breast cancers. This finding confirms the previous observations. This early influence of HPVs may be the reason why there is no increase in the prevalence of HPV-associated breast cancer in immunocompromised patients as compared to HPV-associated cervical cancer.

KW - Benign breast

KW - Breast cancer

KW - Cervimax

KW - HPV E7 protein

KW - Human papilloma virus (HPV)

KW - Immunohistochemistry

KW - Normal breast

KW - PCR

UR - https://www.scopus.com/pages/publications/84982273830

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DO - 10.4137/BCBCR.S35692

M3 - Article

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AN - SCOPUS:84982273830

SN - 1178-2234

VL - 2015

SP - 93

EP - 97

JO - Breast Cancer: Basic and Clinical Research

JF - Breast Cancer: Basic and Clinical Research

IS - 9

ER -

Early human Papilloma virus (HPV) Oncogenic influences in breast cancer

Abstract

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