Early life influences on hearing in adulthood: a systematic review and two-step individual patient data meta-analysis

Piers Dawes, John Newall, Petra L. Graham, Clive Osmond, Mikaela B. von Bonsdorff, Johan Gunnar Eriksson

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)
56 Downloads (Pure)

Abstract

OBJECTIVES: Adverse prenatal and early childhood development may increase susceptibility of hearing loss in adulthood. The objective was to assess whether indices of early development are associated with adult-onset hearing loss in adults ≥18 years.

DESIGN: In a systematic review and meta-analysis, four electronic databases were searched for studies reporting associations between indices of early development (birth weight and adult height) and adult-onset hearing loss in adults ≥18 years. We screened studies, extracted data, and assessed risk of bias. Authors were contacted to provide adjusted odds ratios from a logistic regression model for relationships between birth weight/adult height and normal/impaired hearing enabling a two-step individual patient data random-effects meta-analysis to be carried out. The study is registered with PROSPERO, CRD42020152214.

RESULTS: Four studies of birth weight and seven of adult height were identified. Three studies reported smaller birth weight associated with poorer adult hearing. Six studies reported shorter height associated with poorer hearing. Risk of bias was low to moderate. Four studies provided data for two-step individual patient data random-effects meta-analysis. Odds of hearing impairment were 13.5% lower for every 1 kg increase in birth weight [OR: 0.865 (95% confidence interval: 0.824 to 0.909)] in adulthood over two studies (N=81,289). Every 1 cm increase in height was associated with a 3% reduction in the odds of hearing impairment [OR: 0.970 (95% confidence interval: 0.968 to 0.971)] over four studies (N=156,740).

CONCLUSIONS: Emerging evidence suggests that adverse early development increases the likelihood of hearing impairment in adulthood. Research and public health attention should focus on the potential for prevention of hearing impairment by optimizing development in early life.

Original languageEnglish
Pages (from-to)722–732
Number of pages11
JournalEar and Hearing
Volume43
Issue number3
Early online date8 Dec 2021
DOIs
Publication statusPublished - May 2022

Bibliographical note

Copyright the Author(s) 2021. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • birth weight
  • developmental hypothesis of disease
  • fetal origins
  • hearing

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