Early magnocellular loss in glaucoma demonstrated using the pseudorandomly stimulated flash visual evoked potential

A. I. Klistorner*, S. L. Graham

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)

Abstract

Purpose: Components of the pseudorandomly stimulated flash visual evoked potential (VEP) have now been identified that appear to arise predominantly from each of the magnocellular (M-cell) and parvocellular (P-cell) systems. In this study, the relative damage to magnocellular and parvocellular systems at different stages of glaucoma using pseudorandomly stimulated flash VEP was investigated. Methods: Pseudorandomly stimulated flash VEP was recorded in 15 normal eyes and 28 eyes with different stages of glaucoma using the VERIS-3 recording system (Electro-Diagnostic Imaging, San Francisco, CA). Two levels of luminance contrast of the stimulus (32% and 99%) were tested. The first slice of the second-order kernel from only the central (8°) stimulated area was extracted for analysis. Results: Data recorded from normal eyes demonstrated early saturation of the response/contrast function of the first slice of the second-order kernel. The ratio of the VEP amplitude recorded at 32% and 99% of the luminance contrast was close to unity. In eyes with early glaucoma, although the amplitude of the responses to both low- and high-contrast stimulation decreased, the relative reduction of the low-contrast VEP (M-cell) was more prominent. However, the amplitude of the high-contrast response (P-cell) declined more rapidly later in the disease. Conclusion: These results are consistent with relatively earlier damage of the magnocellular pathway in glaucoma.

Original languageEnglish
Pages (from-to)140-148
Number of pages9
JournalJournal of Glaucoma
Volume8
Issue number2
Publication statusPublished - 1999
Externally publishedYes

Keywords

  • Glaucoma
  • Magnocellular
  • Multifocal technique
  • Parvocellular
  • Visual evoked potential

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