Early migration of precursor neurons initiates cellular and functional regeneration after spinal cord injury in zebrafish

Celia Vandestadt, Gilles C. Vanwalleghem, Hozana Andrade Castillo, Mei Li, Keith Schulze, Mitra Khabooshan, Emily Don, Minna-Liisa Anko, Ethan Scott, Jan Kaslin

Research output: Contribution to journalArticle

Abstract

Zebrafish have a remarkable capacity to regenerate following spinal cord (SC) injury but the responsible cellular events are not well understood. We used in vivo imaging and genetics to pin-point specific cellular processes controlling SC regeneration in zebrafish. We identified two temporally and mechanistically distinct phases of cellular regeneration in the SC. The initial phase relies on migration of precursor neurons to the injury, enabling rapid functional recovery, and activation of quiescent neural progenitor cells (NPCs). A second phase of regenerative neurogenesis compensates for both the lost tissue and cells depleted due to precursor neuron migration. We propose a critical role of precursor neurons recruitment in initiating neuronal circuit recovery and buying sufficient time for regenerative neurogenesis to take place. Taken together, our data suggests an unanticipated role of precursor cell recruitment in driving neural repair and functional recovery during the regenerative response.
Original languageEnglish
JournalbioRxiv
DOIs
Publication statusSubmitted - 2018

Fingerprint Dive into the research topics of 'Early migration of precursor neurons initiates cellular and functional regeneration after spinal cord injury in zebrafish'. Together they form a unique fingerprint.

Cite this