Early phenotypic differences between Parkinson's disease patients with and without freezing of gait

J. M. Hall*, J. M. Shine, C. C. Walton, M. Gilat, Y. P T Kamsma, S. L. Naismith, S. J G Lewis

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


Background: Previous studies have associated freezing of gait in Parkinson's disease with the presence of specific phenotypic features such as mood disturbances, REM sleep behavior disorder and selective cognitive impairments. However, it is not clear whether these features are present in the earlier stages of disease or simply represent a more general pattern of progression. To investigate this issue, the current study evaluated motor, cognitive, affective and autonomic features as well as REM sleep behavior disorder in Parkinson's disease patients in the early stages of the condition. Methods: Thirty-eight freezers and fifty-three non-freezers with disease duration of less than five years and a Hoehn and Yahr stage of less than three were included in this study. The groups were matched on a number of key disease features including age, disease duration, motor severity and dopamine dose equivalence. Furthermore, patients were assessed on measures of motor, cognitive, affective and autonomic features, as well as REM sleep behavior disorder. Results: Compared to non-freezers, patients with freezing of gait had significantly more non-tremor symptoms and a selective impairment on executive functions, such as set-shifting ability and working memory. Freezers and non-freezers did not differ on measures of tremor, autonomic function, REM sleep behavior disorder, mood or more general cognition. Conclusion: These results suggest the pathophysiological mechanisms underlying freezing of gait in the early clinical stages of Parkinson's disease are likely to be related to specific changes in the frontostriatal pathways rather than being due to brainstem or more diffuse neuropathology.

Original languageEnglish
Pages (from-to)604-607
Number of pages4
JournalParkinsonism and Related Disorders
Issue number6
Publication statusPublished - Jun 2014
Externally publishedYes

Bibliographical note

Corrigendum can be found in Parkinsonism and Related Disorders volume 20(9), p 1040, https://doi.org/10.1016/j.parkreldis.2014.06.003


  • autonomic function
  • executive function
  • freezing of gait
  • mood
  • Parkinson's disease
  • REM sleep behavior disorder


Dive into the research topics of 'Early phenotypic differences between Parkinson's disease patients with and without freezing of gait'. Together they form a unique fingerprint.

Cite this