ECG wavelet analysis for the detection of gene mutations in patients with Brugada syndrome

V. N. Batchvarov; G. Bortolan; I. I. Christov; R. Bastiaenen; H. Raju; A. Naseef; E. R. Behr

ECG wavelet analysis for the detection of gene mutations in patients with Brugada syndrome

V. N. Batchvarov^*, G. Bortolan, I. I. Christov, R. Bastiaenen, H. Raju, A. Naseef, E. R. Behr

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution › peer-review

2 Citations (Scopus)

Abstract

We applied wavelet transform (WT) to digital electrocardiograms (ECG) acquired during positive ajmaline test for Brugada syndrome (BrS) in 12 patients (pts) with and 14 pts without gene mutations. Continuous WT was applied to the QRS complex and the ST-T wave on leads V1 to V3 in 4^th and 3 ^rd intercostal space (i.c.s.) (Group A, 13 pts) and leads V1 and V2 from 4^th, 3^rd and 2^nd i.c.s. (Group B, 13 pts) using 256 levels. In group A, there was significantly higher QRS energy at high frequencies in pts with mutations (n=4) both at baseline and during maximum drug effect. In group B, patients with mutations (n=7) had higher QRS energy at low frequencies and higher ST-T energy at low frequencies at baseline and during drug effect. Continuous WT can help identify carriers of gene mutations among patients with BrS, especially when applied to leads V1 and V2 from the 4 ^th to 2^nd i.c.s.

Original language	English
Title of host publication	Computing in Cardiology 2011, CinC 2011
Pages	785-788
Number of pages	4
Volume	38
Publication status	Published - 1 Dec 2011
Externally published	Yes
Event	Computing in Cardiology 2011, CinC 2011 - Hangzhou, China Duration: 18 Sep 2011 → 21 Sep 2011

Conference

Conference	Computing in Cardiology 2011, CinC 2011
Country/Territory	China
City	Hangzhou
Period	18/09/11 → 21/09/11

Cite this

@inproceedings{8de3083a4f7c415b8b4bb6b08ae2ebbf,

title = "ECG wavelet analysis for the detection of gene mutations in patients with Brugada syndrome",

abstract = "We applied wavelet transform (WT) to digital electrocardiograms (ECG) acquired during positive ajmaline test for Brugada syndrome (BrS) in 12 patients (pts) with and 14 pts without gene mutations. Continuous WT was applied to the QRS complex and the ST-T wave on leads V1 to V3 in 4th and 3 rd intercostal space (i.c.s.) (Group A, 13 pts) and leads V1 and V2 from 4th, 3rd and 2nd i.c.s. (Group B, 13 pts) using 256 levels. In group A, there was significantly higher QRS energy at high frequencies in pts with mutations (n=4) both at baseline and during maximum drug effect. In group B, patients with mutations (n=7) had higher QRS energy at low frequencies and higher ST-T energy at low frequencies at baseline and during drug effect. Continuous WT can help identify carriers of gene mutations among patients with BrS, especially when applied to leads V1 and V2 from the 4 th to 2nd i.c.s.",

author = "Batchvarov, {V. N.} and G. Bortolan and Christov, {I. I.} and R. Bastiaenen and H. Raju and A. Naseef and Behr, {E. R.}",

year = "2011",

month = dec,

day = "1",

language = "English",

isbn = "9781457706127",

volume = "38",

pages = "785--788",

booktitle = "Computing in Cardiology 2011, CinC 2011",

note = "Computing in Cardiology 2011, CinC 2011 ; Conference date: 18-09-2011 Through 21-09-2011",

}

ECG wavelet analysis for the detection of gene mutations in patients with Brugada syndrome. / Batchvarov, V. N.; Bortolan, G.; Christov, I. I.; Bastiaenen, R.; Raju, H.; Naseef, A.; Behr, E. R.

Computing in Cardiology 2011, CinC 2011. Vol. 38 2011. p. 785-788 6164683.

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution › peer-review

TY - GEN

T1 - ECG wavelet analysis for the detection of gene mutations in patients with Brugada syndrome

AU - Batchvarov, V. N.

AU - Bortolan, G.

AU - Christov, I. I.

AU - Bastiaenen, R.

AU - Raju, H.

AU - Naseef, A.

AU - Behr, E. R.

PY - 2011/12/1

Y1 - 2011/12/1

N2 - We applied wavelet transform (WT) to digital electrocardiograms (ECG) acquired during positive ajmaline test for Brugada syndrome (BrS) in 12 patients (pts) with and 14 pts without gene mutations. Continuous WT was applied to the QRS complex and the ST-T wave on leads V1 to V3 in 4th and 3 rd intercostal space (i.c.s.) (Group A, 13 pts) and leads V1 and V2 from 4th, 3rd and 2nd i.c.s. (Group B, 13 pts) using 256 levels. In group A, there was significantly higher QRS energy at high frequencies in pts with mutations (n=4) both at baseline and during maximum drug effect. In group B, patients with mutations (n=7) had higher QRS energy at low frequencies and higher ST-T energy at low frequencies at baseline and during drug effect. Continuous WT can help identify carriers of gene mutations among patients with BrS, especially when applied to leads V1 and V2 from the 4 th to 2nd i.c.s.

AB - We applied wavelet transform (WT) to digital electrocardiograms (ECG) acquired during positive ajmaline test for Brugada syndrome (BrS) in 12 patients (pts) with and 14 pts without gene mutations. Continuous WT was applied to the QRS complex and the ST-T wave on leads V1 to V3 in 4th and 3 rd intercostal space (i.c.s.) (Group A, 13 pts) and leads V1 and V2 from 4th, 3rd and 2nd i.c.s. (Group B, 13 pts) using 256 levels. In group A, there was significantly higher QRS energy at high frequencies in pts with mutations (n=4) both at baseline and during maximum drug effect. In group B, patients with mutations (n=7) had higher QRS energy at low frequencies and higher ST-T energy at low frequencies at baseline and during drug effect. Continuous WT can help identify carriers of gene mutations among patients with BrS, especially when applied to leads V1 and V2 from the 4 th to 2nd i.c.s.

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M3 - Conference proceeding contribution

AN - SCOPUS:84859986879

SN - 9781457706127

VL - 38

SP - 785

EP - 788

BT - Computing in Cardiology 2011, CinC 2011

T2 - Computing in Cardiology 2011, CinC 2011

Y2 - 18 September 2011 through 21 September 2011

ER -

ECG wavelet analysis for the detection of gene mutations in patients with Brugada syndrome

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