TY - JOUR
T1 - Ecionines A and B, two new cytotoxic pyridoacridine alkaloids from the Australian marine sponge, Ecionemia geodides
AU - Barnes, Emma C.
AU - Said, Nur Akmarina B M
AU - Williams, Elizabeth D.
AU - Hooper, John N A
AU - Davis, Rohan A.
PY - 2010/1/2
Y1 - 2010/1/2
N2 - Chemical investigations of the Australian marine sponge Ecionemia geodides resulted in the isolation of two new pyridoacridine alkaloids, ecionines A (1) and B (2), along with the previously isolated marine natural products, biemnadin (3) and meridine (4). Compounds 1 and 2 both contain an imine moiety, which is rare for the pyridoacridine structure class. The chemical structures of 1 and 2 were determined by extensive 1D and 2D NMR and MS data analyses. All compounds were tested against a panel of human bladder cancer cell lines, the increasingly metastatic TSU-Pr1 series (TSU-Pr1, TSU-Pr1-B1 and TSU-Pr1-B2) and the superficial bladder cancer cell line 5637. Ecionine A (1) displayed cytotoxicity against all cell lines, with IC50 values ranging from 3 to 7 μM. This is the first report of chemistry from the sponge genus Ecionemia. Crown
AB - Chemical investigations of the Australian marine sponge Ecionemia geodides resulted in the isolation of two new pyridoacridine alkaloids, ecionines A (1) and B (2), along with the previously isolated marine natural products, biemnadin (3) and meridine (4). Compounds 1 and 2 both contain an imine moiety, which is rare for the pyridoacridine structure class. The chemical structures of 1 and 2 were determined by extensive 1D and 2D NMR and MS data analyses. All compounds were tested against a panel of human bladder cancer cell lines, the increasingly metastatic TSU-Pr1 series (TSU-Pr1, TSU-Pr1-B1 and TSU-Pr1-B2) and the superficial bladder cancer cell line 5637. Ecionine A (1) displayed cytotoxicity against all cell lines, with IC50 values ranging from 3 to 7 μM. This is the first report of chemistry from the sponge genus Ecionemia. Crown
UR - http://www.scopus.com/inward/record.url?scp=70549098722&partnerID=8YFLogxK
U2 - 10.1016/j.tet.2009.10.109
DO - 10.1016/j.tet.2009.10.109
M3 - Article
AN - SCOPUS:70549098722
SN - 0040-4020
VL - 66
SP - 283
EP - 287
JO - Tetrahedron
JF - Tetrahedron
IS - 1
ER -