Eco-friendly biosynthesis, anticancer drug loading and cytotoxic effect of capped ag-nanoparticles against breast cancer

M. Naz, N. Nasiri, M. Ikram*, M. Nafees, M. Z. Qureshi, S. Ali, A. Tricoli

*Corresponding author for this work

Research output: Contribution to journalArticle

16 Citations (Scopus)
5 Downloads (Pure)

Abstract

The work aimed to prepare silver nanoparticles (Ag-NPs) from silver nitrate and various concentrations of the seed extract (Setaria verticillata) by a green synthetic route. The chemical and physical properties of the resulting Ag-NPs were investigated by X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectrometry and ultraviolet–visible (UV–Vis) spectrophotometry. Anticancer activity of Ag-NPs (5–20 nm) had dose-dependent cytotoxic effect against breast cancer (MCF7-FLV) cells. The in vitro toxicity was studied on adult earthworms (Lumbricina) resulting in statistically significant (P < 0.05) inhibition. The prepared NPs were loaded with hydrophilic anticancer drugs (ACD), doxorubicin (DOX) and daunorubicin (DNR), for developing a novel drug delivery carrier having significant adsorption capacity and efficiency to remove the side effects of the medicines effective for leukemia chemotherapy.

Original languageEnglish
Pages (from-to)793-802
Number of pages10
JournalApplied Nanoscience (Switzerland)
Volume7
Issue number8
DOIs
Publication statusPublished - Nov 2017
Externally publishedYes

Bibliographical note

Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • Drug loading
  • Seed extract
  • Cytotoxicity
  • Anthelmintic activity
  • Ag-NPs

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