Eco-friendly biosynthesis, anticancer drug loading and cytotoxic effect of capped ag-nanoparticles against breast cancer

M. Naz; N. Nasiri; M. Ikram; M. Nafees; M. Z. Qureshi; S. Ali; A. Tricoli

doi:10.1007/s13204-017-0615-6

Eco-friendly biosynthesis, anticancer drug loading and cytotoxic effect of capped ag-nanoparticles against breast cancer

M. Naz, N. Nasiri, M. Ikram^*, M. Nafees, M. Z. Qureshi, S. Ali, A. Tricoli

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

65 Citations (Scopus)

76 Downloads (Pure)

Abstract

The work aimed to prepare silver nanoparticles (Ag-NPs) from silver nitrate and various concentrations of the seed extract (Setaria verticillata) by a green synthetic route. The chemical and physical properties of the resulting Ag-NPs were investigated by X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectrometry and ultraviolet–visible (UV–Vis) spectrophotometry. Anticancer activity of Ag-NPs (5–20 nm) had dose-dependent cytotoxic effect against breast cancer (MCF7-FLV) cells. The in vitro toxicity was studied on adult earthworms (Lumbricina) resulting in statistically significant (P < 0.05) inhibition. The prepared NPs were loaded with hydrophilic anticancer drugs (ACD), doxorubicin (DOX) and daunorubicin (DNR), for developing a novel drug delivery carrier having significant adsorption capacity and efficiency to remove the side effects of the medicines effective for leukemia chemotherapy.

Original language	English
Pages (from-to)	793-802
Number of pages	10
Journal	Applied Nanoscience
Volume	7
Issue number	8
DOIs	https://doi.org/10.1007/s13204-017-0615-6
Publication status	Published - Nov 2017
Externally published	Yes

Bibliographical note

Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

Drug loading
Seed extract
Cytotoxicity
Anthelmintic activity
Ag-NPs

Access to Document

10.1007/s13204-017-0615-6Licence: CC BY

Publisher version (open access)Final published version, 3.27 MBLicence: CC BY

Cite this

@article{692abf1a8d7645bd8a2b4af7ece86396,

title = "Eco-friendly biosynthesis, anticancer drug loading and cytotoxic effect of capped ag-nanoparticles against breast cancer",

abstract = "The work aimed to prepare silver nanoparticles (Ag-NPs) from silver nitrate and various concentrations of the seed extract (Setaria verticillata) by a green synthetic route. The chemical and physical properties of the resulting Ag-NPs were investigated by X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectrometry and ultraviolet–visible (UV–Vis) spectrophotometry. Anticancer activity of Ag-NPs (5–20 nm) had dose-dependent cytotoxic effect against breast cancer (MCF7-FLV) cells. The in vitro toxicity was studied on adult earthworms (Lumbricina) resulting in statistically significant (P < 0.05) inhibition. The prepared NPs were loaded with hydrophilic anticancer drugs (ACD), doxorubicin (DOX) and daunorubicin (DNR), for developing a novel drug delivery carrier having significant adsorption capacity and efficiency to remove the side effects of the medicines effective for leukemia chemotherapy.",

keywords = "Drug loading, Seed extract, Cytotoxicity, Anthelmintic activity, Ag-NPs",

author = "M. Naz and N. Nasiri and M. Ikram and M. Nafees and Qureshi, {M. Z.} and S. Ali and A. Tricoli",

note = "Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

year = "2017",

month = nov,

doi = "10.1007/s13204-017-0615-6",

language = "English",

volume = "7",

pages = "793--802",

journal = "Applied Nanoscience",

issn = "2190-5509",

publisher = "Springer, Springer Nature",

number = "8",

}

TY - JOUR

T1 - Eco-friendly biosynthesis, anticancer drug loading and cytotoxic effect of capped ag-nanoparticles against breast cancer

AU - Naz, M.

AU - Nasiri, N.

AU - Ikram, M.

AU - Nafees, M.

AU - Qureshi, M. Z.

AU - Ali, S.

AU - Tricoli, A.

N1 - Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2017/11

Y1 - 2017/11

N2 - The work aimed to prepare silver nanoparticles (Ag-NPs) from silver nitrate and various concentrations of the seed extract (Setaria verticillata) by a green synthetic route. The chemical and physical properties of the resulting Ag-NPs were investigated by X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectrometry and ultraviolet–visible (UV–Vis) spectrophotometry. Anticancer activity of Ag-NPs (5–20 nm) had dose-dependent cytotoxic effect against breast cancer (MCF7-FLV) cells. The in vitro toxicity was studied on adult earthworms (Lumbricina) resulting in statistically significant (P < 0.05) inhibition. The prepared NPs were loaded with hydrophilic anticancer drugs (ACD), doxorubicin (DOX) and daunorubicin (DNR), for developing a novel drug delivery carrier having significant adsorption capacity and efficiency to remove the side effects of the medicines effective for leukemia chemotherapy.

AB - The work aimed to prepare silver nanoparticles (Ag-NPs) from silver nitrate and various concentrations of the seed extract (Setaria verticillata) by a green synthetic route. The chemical and physical properties of the resulting Ag-NPs were investigated by X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectrometry and ultraviolet–visible (UV–Vis) spectrophotometry. Anticancer activity of Ag-NPs (5–20 nm) had dose-dependent cytotoxic effect against breast cancer (MCF7-FLV) cells. The in vitro toxicity was studied on adult earthworms (Lumbricina) resulting in statistically significant (P < 0.05) inhibition. The prepared NPs were loaded with hydrophilic anticancer drugs (ACD), doxorubicin (DOX) and daunorubicin (DNR), for developing a novel drug delivery carrier having significant adsorption capacity and efficiency to remove the side effects of the medicines effective for leukemia chemotherapy.

KW - Drug loading

KW - Seed extract

KW - Cytotoxicity

KW - Anthelmintic activity

KW - Ag-NPs

UR - http://www.scopus.com/inward/record.url?scp=85056482667&partnerID=8YFLogxK

U2 - 10.1007/s13204-017-0615-6

DO - 10.1007/s13204-017-0615-6

M3 - Article

AN - SCOPUS:85056482667

SN - 2190-5509

VL - 7

SP - 793

EP - 802

JO - Applied Nanoscience

JF - Applied Nanoscience

IS - 8

ER -

Eco-friendly biosynthesis, anticancer drug loading and cytotoxic effect of capped ag-nanoparticles against breast cancer

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this