Effect of dosing cup size on the aerosol performance of high-dose carrier-based formulations in a novel dry powder inhaler

Stewart Yeung, Daniela Traini, Alan Tweedie, David Lewis, Tanya Church, Paul M. Young*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

This study investigated how varying the dosing cup size of a novel reservoir dry powder inhaler (DPI) affects the detachment of a micronized active pharmaceutical ingredient from larger carrier particles, and the aerosol performance of a DPI carrier formulation. Three different-sized dosing cups were designed: 3D printed with cup volumes of 16.26 mm3 , 55.99 mm3 , and 133.04 mm3 , and tested with five different carrier type formulations with beclomethasone dipropionate (BDP) concentrations between 1% and 30% (w/w). The morphology of the BDP attached to the carrier was investigated using scanning electron microscopy and the aerosol performance using the Next Generation Impactor. Increasing the volume of the dosing cup led to a reduction of BDP deposition in the Next Generation Impactor preseparator, and an increase in BDP detachment from the carrier was observed, leading to increased aerosol performance. The decreased amount of BDP attached to carrier after aerosolization was attributed to the increased dosing cup void volume. This may enable greater particle-particle and particle-wall collisions, with greater BDP detachment from the carrier and deagglomeration of smaller agglomerates. The dosing cup volume was observed to have significant influence on particle dispersion and the overall aerosol performance of a DPI.

Original languageEnglish
Pages (from-to)949-959
Number of pages11
JournalJournal of Pharmaceutical Sciences
Volume108
Issue number2
DOIs
Publication statusPublished - Feb 2019
Externally publishedYes

Keywords

  • aerosol performance
  • carrier formulation
  • dosing cup size
  • impaction forces
  • reservoir-based dry powder inhaler

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