Effect of enhanced voluntary physical exercise on brain levels of monoamines in Huntington disease mice

Thibault Renoir*, Caroline Chevarin, Laurence Lanfumey-Mongredien, Anthony J. Hannan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Using the R6/1 mouse model of Huntington disease (HD), we have recently shown that voluntary physical activity was able to correct the depressive-like behaviours exhibited by the HD animals at a pre-motor symptomatic stage of the disease. Using the high performance liquid chromatography system, we have now evaluated the effect of exercise on monoamine metabolism in HD mice. We found that serotonin and its metabolite as well as dopamine and noradrenaline were reduced across several brain regions in female R6/1 animals. Our data also suggest that some of these neurochemical deficits were modulated by physical activity, in a genotype-region dependent manner. These newly identified changes could account for some of the behavioural effects of exercise previously reported in HD mice.

Original languageEnglish
Article numberRRN1281
Pages (from-to)1-12
Number of pages12
JournalPLoS Currents
VolumeHD MODELS
Issue number1
DOIs
Publication statusPublished - 4 Nov 2011
Externally publishedYes

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