TY - JOUR
T1 - Effect of BDNF Val66Met on memory decline and hippocampal atrophy in prodromal Alzheimer's Disease
T2 - a preliminary study
AU - Lim, Yen Ying
AU - Villemagne, Victor L.
AU - Laws, Simon M.
AU - Ames, David
AU - Pietrzak, Robert H.
AU - Ellis, Kathryn A.
AU - Harrington, Karra
AU - Bourgeat, Pierrick
AU - Bush, Ashley I.
AU - Martins, Ralph N.
AU - Masters, Colin L.
AU - Rowe, Christopher C.
AU - Maruff, Paul
PY - 2014/1/27
Y1 - 2014/1/27
N2 - Objective: Cross-sectional genetic association studies have reported equivocal results on the relationship between the brain-derived neurotrophic factor (BDNF) Val66Met and risk of Alzheimer's disease (AD). As AD is a neurodegenerative disease, genetic influences may become clearer from prospective study. We aimed to determine whether BDNF Val66Met polymorphism influences changes in memory performance, hippocampal volume, and Aβ accumulation in adults with amnestic mild cognitive impairment (aMCI) and high Aβ. Methods: Thirty-four adults with aMCI were recruited from the Australian, Imaging, Biomarkers and Lifestyle (AIBL) Study. Participants underwent PiB-PET and structural MRI neuroimaging, neuropsychological assessments and BDNF genotyping at baseline, 18 month, and 36 month assessments. Results: In individuals with aMCI and high Aβ, Met carriers showed significant and large decline in episodic memory (d = 0.90, p = .020) and hippocampal volume (d = 0.98, p = .035). BDNF Val66Met was unrelated to the rate of Aβ accumulation (d = -0.35, p = .401). Conclusions: Although preliminary due to the small sample size, results of this study suggest that high Aβ levels and Met carriage may be useful prognostic markers of accelerated decline in episodic memory, and reductions in hippocampal volume in individuals in the prodromal or MCI stage of AD.
AB - Objective: Cross-sectional genetic association studies have reported equivocal results on the relationship between the brain-derived neurotrophic factor (BDNF) Val66Met and risk of Alzheimer's disease (AD). As AD is a neurodegenerative disease, genetic influences may become clearer from prospective study. We aimed to determine whether BDNF Val66Met polymorphism influences changes in memory performance, hippocampal volume, and Aβ accumulation in adults with amnestic mild cognitive impairment (aMCI) and high Aβ. Methods: Thirty-four adults with aMCI were recruited from the Australian, Imaging, Biomarkers and Lifestyle (AIBL) Study. Participants underwent PiB-PET and structural MRI neuroimaging, neuropsychological assessments and BDNF genotyping at baseline, 18 month, and 36 month assessments. Results: In individuals with aMCI and high Aβ, Met carriers showed significant and large decline in episodic memory (d = 0.90, p = .020) and hippocampal volume (d = 0.98, p = .035). BDNF Val66Met was unrelated to the rate of Aβ accumulation (d = -0.35, p = .401). Conclusions: Although preliminary due to the small sample size, results of this study suggest that high Aβ levels and Met carriage may be useful prognostic markers of accelerated decline in episodic memory, and reductions in hippocampal volume in individuals in the prodromal or MCI stage of AD.
UR - http://www.scopus.com/inward/record.url?scp=84899941795&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0086498
DO - 10.1371/journal.pone.0086498
M3 - Article
C2 - 24475133
AN - SCOPUS:84899941795
VL - 9
SP - 1
EP - 5
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 1
M1 - e86498
ER -