Effect of iron chelators with potent anti-proliferative activity on the expression of molecules involved in cell cycle progression and growth

J. Gao, D. Lovejoy, D. R. Richardson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Our previous studies have demonstrated that some analogues of the iron (Fe) chelator, pyridoxal isonicotinoyl hydrazone (PIH), show high anti-proliferative activity being far more effective than desferrioxamine (DFO). In this investigation, we have assessed the effect of DFO and one of the most active chelators, 2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone -311-, on molecular targets involved in proliferation. This was performed to assess the mechanisms involved in the anti-neoplastic activity of Fe chelators.
Original languageEnglish
Pages (from-to)311-312
Number of pages2
JournalRedox Report
Volume4
Issue number6
DOIs
Publication statusPublished - 1 Jan 1999
Externally publishedYes

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