Effect of iron chelators with potent anti-proliferative activity on the expression of molecules involved in cell cycle progression and growth

J. Gao; D. Lovejoy; D. R. Richardson

doi:10.1179/135100099101534990

Effect of iron chelators with potent anti-proliferative activity on the expression of molecules involved in cell cycle progression and growth

J. Gao, D. Lovejoy, D. R. Richardson^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Our previous studies have demonstrated that some analogues of the iron (Fe) chelator, pyridoxal isonicotinoyl hydrazone (PIH), show high anti-proliferative activity being far more effective than desferrioxamine (DFO). In this investigation, we have assessed the effect of DFO and one of the most active chelators, 2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone -311-, on molecular targets involved in proliferation. This was performed to assess the mechanisms involved in the anti-neoplastic activity of Fe chelators.

Original language	English
Pages (from-to)	311-312
Number of pages	2
Journal	Redox Report
Volume	4
Issue number	6
DOIs	https://doi.org/10.1179/135100099101534990
Publication status	Published - 1 Jan 1999
Externally published	Yes

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AU - Richardson, D. R.

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Y1 - 1999/1/1

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AB - Our previous studies have demonstrated that some analogues of the iron (Fe) chelator, pyridoxal isonicotinoyl hydrazone (PIH), show high anti-proliferative activity being far more effective than desferrioxamine (DFO). In this investigation, we have assessed the effect of DFO and one of the most active chelators, 2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone -311-, on molecular targets involved in proliferation. This was performed to assess the mechanisms involved in the anti-neoplastic activity of Fe chelators.

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Effect of iron chelators with potent anti-proliferative activity on the expression of molecules involved in cell cycle progression and growth

Abstract

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