Effect of neural activity on skeletal muscle phosphoproteins

Garth A. Nicholson*, Scott Hawkins, James G. McLeod

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


A number of phosphoproteins were found in the soluble fraction of rat skeletal muscle by two‐dimensional polyacrylamide gel electrophoresis (PAGE). The pattern of some of these phosphoproteins differed in fast (extensor digitorum longus, EDL) or slow (soleus) muscles, was dependent on normal innervation, and was altered with denervation. In order to determine if the pattern was maintained by electrical activity or trophic factors, we compared the effect of electrical block by local neural application of tetrodotoxin with the effect of complete nerve section. Both methods produced similar alterations in phosphoproteins, indicating that the pattern is dependent on nerve activity, not trophic factors. Such phosphoproteins are possible mediators of neural activity on gene expression.

Original languageEnglish
Pages (from-to)675-680
Number of pages6
JournalMuscle and Nerve
Issue number8
Publication statusPublished - 1990
Externally publishedYes


  • fiber type
  • neural activity
  • phosphoproteins
  • skeletal muscle


Dive into the research topics of 'Effect of neural activity on skeletal muscle phosphoproteins'. Together they form a unique fingerprint.

Cite this