TY - JOUR
T1 - Effect of novel synthetic evodiamine analogue on sexual behavior in male rats
AU - Vyawahare, Neeraj S.
AU - Hadambar, Avinash A.
AU - Chothe, Aparna S.
AU - Jalnapurkar, Rajeshwar R.
AU - Bhandare, Amol M.
AU - Kathiravan, Muthu K.
PY - 2012/1
Y1 - 2012/1
N2 - Currently phosphodiestrase5 (PDE5) inhibitors are the first-line treatment for erectile dysfunction. Drugs such as sildenafil and tadalafil are available as PDE5 inhibitors which are potent and reversible but lack selectivity with side effects such as headache, facial flushing, dyspepsia, and visual disturbances. We herein report for the first time novel condensed thienopyrimidines as evodiamine analogue and their effect on sexual behavior in male rats hitherto unreported. Novel synthetic evodiamine significantly showed improvement in male rat copulatory behavior. The test compound MKAC9 could be of promising importance in the treatment of sexual disorders like desire disorder or erectile dysfunction.
AB - Currently phosphodiestrase5 (PDE5) inhibitors are the first-line treatment for erectile dysfunction. Drugs such as sildenafil and tadalafil are available as PDE5 inhibitors which are potent and reversible but lack selectivity with side effects such as headache, facial flushing, dyspepsia, and visual disturbances. We herein report for the first time novel condensed thienopyrimidines as evodiamine analogue and their effect on sexual behavior in male rats hitherto unreported. Novel synthetic evodiamine significantly showed improvement in male rat copulatory behavior. The test compound MKAC9 could be of promising importance in the treatment of sexual disorders like desire disorder or erectile dysfunction.
KW - Aphrodisiac
KW - Evodiamine
KW - PDE5 inhibitors
KW - Thienopyrimidine derivative
UR - http://www.scopus.com/inward/record.url?scp=84859801256&partnerID=8YFLogxK
U2 - 10.1007/s12154-011-0067-5
DO - 10.1007/s12154-011-0067-5
M3 - Article
C2 - 23049645
AN - SCOPUS:84859801256
VL - 5
SP - 35
EP - 42
JO - Journal of Chemical Biology
JF - Journal of Chemical Biology
SN - 1864-6158
IS - 1
ER -