Effect of novel synthetic evodiamine analogue on sexual behavior in male rats

Neeraj S. Vyawahare; Avinash A. Hadambar; Aparna S. Chothe; Rajeshwar R. Jalnapurkar; Amol M. Bhandare; Muthu K. Kathiravan

doi:10.1007/s12154-011-0067-5

Effect of novel synthetic evodiamine analogue on sexual behavior in male rats

Neeraj S. Vyawahare, Avinash A. Hadambar, Aparna S. Chothe, Rajeshwar R. Jalnapurkar, Amol M. Bhandare, Muthu K. Kathiravan^*

^*Corresponding author for this work

Faculty of Medicine, Health and Human Sciences

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Currently phosphodiestrase5 (PDE5) inhibitors are the first-line treatment for erectile dysfunction. Drugs such as sildenafil and tadalafil are available as PDE5 inhibitors which are potent and reversible but lack selectivity with side effects such as headache, facial flushing, dyspepsia, and visual disturbances. We herein report for the first time novel condensed thienopyrimidines as evodiamine analogue and their effect on sexual behavior in male rats hitherto unreported. Novel synthetic evodiamine significantly showed improvement in male rat copulatory behavior. The test compound MKAC9 could be of promising importance in the treatment of sexual disorders like desire disorder or erectile dysfunction.

Original language	English
Pages (from-to)	35-42
Number of pages	8
Journal	Journal of Chemical Biology
Volume	5
Issue number	1
DOIs	https://doi.org/10.1007/s12154-011-0067-5
Publication status	Published - Jan 2012

Keywords

Aphrodisiac
Evodiamine
PDE5 inhibitors
Thienopyrimidine derivative

Access to Document

10.1007/s12154-011-0067-5

Cite this

@article{0cf3f7f0a1214c3ab5100a72ef7520e4,

title = "Effect of novel synthetic evodiamine analogue on sexual behavior in male rats",

abstract = "Currently phosphodiestrase5 (PDE5) inhibitors are the first-line treatment for erectile dysfunction. Drugs such as sildenafil and tadalafil are available as PDE5 inhibitors which are potent and reversible but lack selectivity with side effects such as headache, facial flushing, dyspepsia, and visual disturbances. We herein report for the first time novel condensed thienopyrimidines as evodiamine analogue and their effect on sexual behavior in male rats hitherto unreported. Novel synthetic evodiamine significantly showed improvement in male rat copulatory behavior. The test compound MKAC9 could be of promising importance in the treatment of sexual disorders like desire disorder or erectile dysfunction.",

keywords = "Aphrodisiac, Evodiamine, PDE5 inhibitors, Thienopyrimidine derivative",

author = "Vyawahare, {Neeraj S.} and Hadambar, {Avinash A.} and Chothe, {Aparna S.} and Jalnapurkar, {Rajeshwar R.} and Bhandare, {Amol M.} and Kathiravan, {Muthu K.}",

year = "2012",

month = jan,

doi = "10.1007/s12154-011-0067-5",

language = "English",

volume = "5",

pages = "35--42",

journal = "Journal of Chemical Biology",

issn = "1864-6158",

publisher = "Springer, Springer Nature",

number = "1",

}

TY - JOUR

T1 - Effect of novel synthetic evodiamine analogue on sexual behavior in male rats

AU - Vyawahare, Neeraj S.

AU - Hadambar, Avinash A.

AU - Chothe, Aparna S.

AU - Jalnapurkar, Rajeshwar R.

AU - Bhandare, Amol M.

AU - Kathiravan, Muthu K.

PY - 2012/1

Y1 - 2012/1

N2 - Currently phosphodiestrase5 (PDE5) inhibitors are the first-line treatment for erectile dysfunction. Drugs such as sildenafil and tadalafil are available as PDE5 inhibitors which are potent and reversible but lack selectivity with side effects such as headache, facial flushing, dyspepsia, and visual disturbances. We herein report for the first time novel condensed thienopyrimidines as evodiamine analogue and their effect on sexual behavior in male rats hitherto unreported. Novel synthetic evodiamine significantly showed improvement in male rat copulatory behavior. The test compound MKAC9 could be of promising importance in the treatment of sexual disorders like desire disorder or erectile dysfunction.

AB - Currently phosphodiestrase5 (PDE5) inhibitors are the first-line treatment for erectile dysfunction. Drugs such as sildenafil and tadalafil are available as PDE5 inhibitors which are potent and reversible but lack selectivity with side effects such as headache, facial flushing, dyspepsia, and visual disturbances. We herein report for the first time novel condensed thienopyrimidines as evodiamine analogue and their effect on sexual behavior in male rats hitherto unreported. Novel synthetic evodiamine significantly showed improvement in male rat copulatory behavior. The test compound MKAC9 could be of promising importance in the treatment of sexual disorders like desire disorder or erectile dysfunction.

KW - Aphrodisiac

KW - Evodiamine

KW - PDE5 inhibitors

KW - Thienopyrimidine derivative

UR - http://www.scopus.com/inward/record.url?scp=84859801256&partnerID=8YFLogxK

U2 - 10.1007/s12154-011-0067-5

DO - 10.1007/s12154-011-0067-5

M3 - Article

C2 - 23049645

AN - SCOPUS:84859801256

VL - 5

SP - 35

EP - 42

JO - Journal of Chemical Biology

JF - Journal of Chemical Biology

SN - 1864-6158

IS - 1

ER -

Effect of novel synthetic evodiamine analogue on sexual behavior in male rats

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this