Effect of novel synthetic evodiamine analogue on sexual behavior in male rats

Neeraj S. Vyawahare, Avinash A. Hadambar, Aparna S. Chothe, Rajeshwar R. Jalnapurkar, Amol M. Bhandare, Muthu K. Kathiravan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Currently phosphodiestrase5 (PDE5) inhibitors are the first-line treatment for erectile dysfunction. Drugs such as sildenafil and tadalafil are available as PDE5 inhibitors which are potent and reversible but lack selectivity with side effects such as headache, facial flushing, dyspepsia, and visual disturbances. We herein report for the first time novel condensed thienopyrimidines as evodiamine analogue and their effect on sexual behavior in male rats hitherto unreported. Novel synthetic evodiamine significantly showed improvement in male rat copulatory behavior. The test compound MKAC9 could be of promising importance in the treatment of sexual disorders like desire disorder or erectile dysfunction.

Original languageEnglish
Pages (from-to)35-42
Number of pages8
JournalJournal of Chemical Biology
Issue number1
Publication statusPublished - Jan 2012


  • Aphrodisiac
  • Evodiamine
  • PDE5 inhibitors
  • Thienopyrimidine derivative


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