TY - JOUR
T1 - Effect of Pre-Hospital Ticagrelor During the First 24 h After Primary Percutaneous Coronary Intervention in Patients With ST-Segment Elevation Myocardial Infarction
T2 - the ATLANTIC-H²⁴ Analysis
AU - Montalescot, Gilles
AU - van 't Hof, Arnoud W.
AU - Bolognese, Leonardo
AU - Cantor, Warren J.
AU - Cequier, Angel
AU - Chettibi, Mohamed
AU - Collet, Jean Philippe
AU - Goodman, Shaun G.
AU - Hammett, Christopher J.
AU - Huber, Kurt
AU - Janzon, Magnus
AU - Lapostolle, Frédéric
AU - Lassen, Jens Flensted
AU - Licour, Muriel
AU - Merkely, Béla
AU - Salhi, Néjoua
AU - Silvain, Johanne
AU - Storey, Robert F.
AU - Ten Berg, Jurriën M.
AU - Tsatsaris, Anne
AU - Zeymer, Uwe
AU - Vicaut, Eric
AU - Hamm, Christian W.
AU - ATLANTIC Investigators
AU - Bougherbal, Rachid
AU - Bouafia, Mohamed Tahar
AU - Nibouche, Djamaleddine
AU - Moklati, Abdelkader
AU - Benalia, Ahmed
AU - Kaid, Omar
AU - Krim, Messaad
AU - Hammett, Christopher
AU - Garrahy, Paul
AU - Jayasinghe, Rohan
AU - Rashford, Stephen
AU - Neunteufl, Thomas
AU - Brussee, Helmut
AU - Alber, Hannes
AU - Weidinger, Franz
AU - Brunner, Michael
AU - Sipoetz, Johann
AU - Prause, Gerhard
AU - Baubin, Michael
AU - Sebald, Dieter
AU - Cantor, Warren
AU - Vijayaraghavan, Ram
AU - Bata, Iqbal
AU - Lavoie, Andrea
AU - Ravkilde, Jan
AU - Jensen, Lisette Okkels
AU - Christensen, Alf Møl
AU - Toftegaard, Marianne
AU - Köhler, Dennis
AU - Ducrocq, Gregory
AU - Danchin, Nicolas
AU - Henry, Patrick
AU - Livarek, Bernard
AU - Berthier, Romain
AU - Hovasse, Thomas
AU - Garot, Philippe
AU - Payot, Laurent
AU - Benamer, Hakim
AU - Esteve, Jean Baptiste
AU - Elhadad, Simon
AU - Teiger, Emmanuel
AU - Bonnet, Jean Louis
AU - Paganelli, Franck
AU - Cottin, Yves
AU - Schiele, François
AU - Thuaire, Christophe
AU - Cayla, Guillaume
AU - Coste, Pierre
AU - Ohlmann, Patrick
AU - Cudraz, Eric Bonnefoy
AU - Lantelme, Pierre
AU - Perret, Thibault
AU - Tron, Christophe
AU - De Labriolle, Axel
AU - Aptecar, Edouardo
AU - Beliard, Olivier
AU - Varenne, Olivier
AU - El Mahmoud, Rami
AU - Filippi-Codaccioni, Emmanuelle
AU - Angoulvant, Denis
AU - Peycher, Patrick
AU - Poitrineau, Olivier
AU - Tabone, Xavier
AU - Ecollan, Patrick
AU - Broche, Claire
AU - Lambert, Yves
AU - Briole, Nicolas
AU - Beruben, Arielle
AU - Porcher, Nicolas
AU - Auffray, Jean Pierre
AU - Freysz, Marc
AU - Depardieu, Franck
AU - Poubel, David
AU - De La Cousaye, Jean Emmanuel
AU - Bartier, Jean Claude
AU - Jardel, Benoît
AU - Boulanger, Bertrand
AU - Labourel, Hervé
AU - Soulat, Louis Christophe
AU - Julie, Véronique
AU - Thicoipe, Michel
AU - Capel, Olivier
AU - Stibbe, Olivier
AU - Carli, Pierre
AU - Tazarourte, Karim
AU - Alcouffe, Fabrice
AU - Aboucaya, David
AU - Aubert, Gaële
AU - Kierzek, Gérald
AU - Cahun-Giraud, Séverine
AU - Hamm, Christian
AU - Dengler, Thomas
AU - Prondzinsky, Roland
AU - Biever, Paul Marc
AU - Schäfer, Andreas
AU - Seyfarth, Melchior
AU - Lemke, Bernd
AU - Werner, Gerald
AU - Nef, Holger
AU - Steiger, Holger
AU - Leschke, Matthias
AU - Münzel, Thomas
AU - Dell Orto, Marco Campo
AU - Loges, Christian
AU - Schinke, Monika
AU - Koberne, Frank
AU - Reiffen, Hans Peter
AU - Tiroch, Klaus
AU - Wierich, Dirk
AU - Kneussel, Michael
AU - Little, Simon
AU - Sauer, Hartmut
AU - Laufenberg-Feldmann, Rita
AU - Ungi, Imre
AU - Horváth, Iván
AU - Édes, István
AU - Mártai, István
AU - Berti, Sergio
AU - Chiarella, Francesco
AU - Calabria, Paolo
AU - Fineschi, Massimo
AU - Galvani, Marcello
AU - Valgimigli, Marco
AU - Moretti, Luciano
AU - Tespili, Maurizio
AU - Mandó, Massimo
AU - Bermano, Francesco
AU - Biagioni, Robusto
AU - Fabbri, Andrea
AU - Ricciardelli, Adelina
AU - Petroni, Maria Romana
AU - Vatteroni, Umberto Roberto
AU - Palumbo, Francesco
AU - Willems, Frank F.
AU - Al Mafragi, Amar
AU - Heestermans, Ton A A C M
AU - Van Eck, Martijn J.
AU - Heutz, Wim M J M
AU - Meppelder, H. H.
AU - Jong, Anika Roukema De
AU - Van De Pas, Harm
AU - Fillat, Ángel Cequier
AU - Tenas, Manel Sabaté
AU - Ferrer, Josepa Mauri
AU - Peñaranda, Antoni Serra
AU - Ferrer, Joan Ángel
AU - Del Blanco, Bruno García
AU - Guardiola, Faustino Miranda
AU - Ruiz Nodar, Juan Miguel
AU - Romo, Andrés Íñiguez
AU - González, Nicolás Vázquez
AU - Nouche, Ramiro Trillo
AU - De La Llera, Luis Díaz
AU - Hernández García, José María
AU - Rivero-Crespo, Fernando
AU - Hernández, Felipe Hernández
AU - Zamorano Gómez, José Luis
AU - Fárega, Xavier Jiménez
AU - Fernández, Gilberto Alonso
AU - Toboso, José Luis
AU - Carrasco, Mercedes
AU - Barreiro, Victoria
AU - Iglesias Vázquez, José Antonio
AU - Montero, María Del Mar Ruiz
AU - Ortiz, Fernando Rosell
AU - Escudero, Guillermo Garcia
AU - Ingelmo, Vicente Sánchez Brunete
AU - García, Antonio Lara
AU - Oldgren, Jonas
AU - Calais, Fredrik
AU - Kastberg, Robert
AU - Bergsten, Per Adolf
AU - Blomberg, Hans
AU - Thörn, Kristian
AU - Skoog, Gunnar
AU - Zaman, Azfar
AU - Gerber, Robert
AU - Ryding, Alisdair
AU - Spence, Mark
AU - Swanson, Neil
AU - Been, Martin
AU - Grosser, Konrad
AU - Schofield, Peter
AU - Mackin, David
AU - Fell, Paul
AU - Quinn, Tom
AU - Foster, Teresa
AU - McManus, David
AU - Carson, Andy
PY - 2016/4/11
Y1 - 2016/4/11
N2 - Objectives: The aim of this landmark exploratory analysis, ATLANTIC-H24, was to evaluate the effects of pre-hospital ticagrelor during the first 24 h after primary percutaneous coronary intervention (PCI) in the ATLANTIC (Administration of Ticagrelor in the cath Lab or in the Ambulance for New ST elevation myocardial infarction to open the Coronary artery) study. Background: The ATLANTIC trial in patients with ongoing ST-segment elevation myocardial infarction showed that pre-hospital ticagrelor was safe but did not improve pre-PCI coronary reperfusion compared with in-hospital ticagrelor. We hypothesized that the effect of pre-hospital ticagrelor may not have manifested until after PCI due to the rapid transfer time (31 min). Methods: The ATLANTIC-H24 analysis included 1,629 patients who underwent PCI, evaluating platelet reactivity, Thrombolysis In Myocardial Infarction flow grade 3, ≥70% ST-segment elevation resolution, and clinical endpoints over the first 24 h. Results: Following PCI, largest between-group differences in platelet reactivity occurred at 1 to 6 h; coronary reperfusion rates numerically favored pre-hospital ticagrelor, and the degree of ST-segment elevation resolution was significantly greater in the pre-hospital group (median, 75.0% vs. 71.4%; p = 0.049). At 24 h, the composite ischemic endpoint was lower with pre-hospital ticagrelor (10.4% vs. 13.7%; p = 0.039), as were individual endpoints of definite stent thrombosis (p = 0.0078) and myocardial infarction (p = 0.031). All endpoints except death (1.1% vs. 0.2%; p = 0.048) favored pre-hospital ticagrelor, with no differences in bleeding events. Conclusions: The effects of pre-hospital ticagrelor became apparent after PCI, with numerical differences in platelet reactivity and immediate post-PCI reperfusion, associated with reductions in ischemic endpoints, over the first 24 h, whereas there was a small excess of mortality. (Administration of Ticagrelor in the cath Lab or in the Ambulance for New ST elevation myocardial infarction to open the Coronary artery [ATLANTIC, NCT01347580])
AB - Objectives: The aim of this landmark exploratory analysis, ATLANTIC-H24, was to evaluate the effects of pre-hospital ticagrelor during the first 24 h after primary percutaneous coronary intervention (PCI) in the ATLANTIC (Administration of Ticagrelor in the cath Lab or in the Ambulance for New ST elevation myocardial infarction to open the Coronary artery) study. Background: The ATLANTIC trial in patients with ongoing ST-segment elevation myocardial infarction showed that pre-hospital ticagrelor was safe but did not improve pre-PCI coronary reperfusion compared with in-hospital ticagrelor. We hypothesized that the effect of pre-hospital ticagrelor may not have manifested until after PCI due to the rapid transfer time (31 min). Methods: The ATLANTIC-H24 analysis included 1,629 patients who underwent PCI, evaluating platelet reactivity, Thrombolysis In Myocardial Infarction flow grade 3, ≥70% ST-segment elevation resolution, and clinical endpoints over the first 24 h. Results: Following PCI, largest between-group differences in platelet reactivity occurred at 1 to 6 h; coronary reperfusion rates numerically favored pre-hospital ticagrelor, and the degree of ST-segment elevation resolution was significantly greater in the pre-hospital group (median, 75.0% vs. 71.4%; p = 0.049). At 24 h, the composite ischemic endpoint was lower with pre-hospital ticagrelor (10.4% vs. 13.7%; p = 0.039), as were individual endpoints of definite stent thrombosis (p = 0.0078) and myocardial infarction (p = 0.031). All endpoints except death (1.1% vs. 0.2%; p = 0.048) favored pre-hospital ticagrelor, with no differences in bleeding events. Conclusions: The effects of pre-hospital ticagrelor became apparent after PCI, with numerical differences in platelet reactivity and immediate post-PCI reperfusion, associated with reductions in ischemic endpoints, over the first 24 h, whereas there was a small excess of mortality. (Administration of Ticagrelor in the cath Lab or in the Ambulance for New ST elevation myocardial infarction to open the Coronary artery [ATLANTIC, NCT01347580])
KW - myocardial infarction
KW - platelets
KW - reperfusion
KW - stents
KW - thrombosis
UR - http://www.scopus.com/inward/record.url?scp=84959464492&partnerID=8YFLogxK
U2 - 10.1016/j.jcin.2015.12.024
DO - 10.1016/j.jcin.2015.12.024
M3 - Article
C2 - 26952907
AN - SCOPUS:84959464492
VL - 9
SP - 646
EP - 656
JO - JACC: Cardiovascular Interventions
JF - JACC: Cardiovascular Interventions
SN - 1936-8798
IS - 7
ER -