Effect of sodium decanoate in aerosol formulations as an absorption enhancer for the para-cellular pathway

Maliheh Ghadiri, Finbar Canny, Paul M. Young, Daniela Traini

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contributionpeer-review

Abstract

The non-invasive delivery of hydrophilic drugs or large biopharmaceuticals to the systemic circulation via the lung is still a big challenge. Presence of intercellular tight junctions strictly limits the absorption of these poorly permeable drugs. Modulating the para-cellular transport could potentially be the solution to overcome this issue. Numerous ions and molecules have been studied as possible absorption enhancers. Sodium (Na) decanoate is a well-studied absorption enhancer and the only excipient approved in the pharmaceutical industry for this purpose. Although the effect of Na decanoate has been investigated in oral and rectal delivery systems, it has not been studied for pulmonary delivery. Therefore, in this study the effect of nebulized Na
decanoate solution on the para-cellular transport and aerosol performances of Na fluorescein (flu-Na), a known para-cellular marker is presented.
Original languageEnglish
Title of host publicationRDD Europe 2017
EditorsR. N. Dalby, J. Peart, J. D. Suman, P. M. Young, D. Traini
Place of PublicationRichmond, VA
PublisherRDD Online
Pages401-404
Number of pages4
Volume2
ISBN (Electronic)9781942911067
Publication statusPublished - 2017
Externally publishedYes
EventRespiratory Drug Delivery Europe 2017 - Antibes, France
Duration: 25 Apr 201728 Apr 2017

Conference

ConferenceRespiratory Drug Delivery Europe 2017
CountryFrance
CityAntibes
Period25/04/1728/04/17

Keywords

  • Na decanoate
  • tight junction
  • epithelial cells
  • calu-3 cells
  • nebulizer
  • para-cellular transport

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