Abstract
The non-invasive delivery of hydrophilic drugs or large biopharmaceuticals to the systemic circulation via the lung is still a big challenge. Presence of intercellular tight junctions strictly limits the absorption of these poorly permeable drugs. Modulating the para-cellular transport could potentially be the solution to overcome this issue. Numerous ions and molecules have been studied as possible absorption enhancers. Sodium (Na) decanoate is a well-studied absorption enhancer and the only excipient approved in the pharmaceutical industry for this purpose. Although the effect of Na decanoate has been investigated in oral and rectal delivery systems, it has not been studied for pulmonary delivery. Therefore, in this study the effect of nebulized Na
decanoate solution on the para-cellular transport and aerosol performances of Na fluorescein (flu-Na), a known para-cellular marker is presented.
decanoate solution on the para-cellular transport and aerosol performances of Na fluorescein (flu-Na), a known para-cellular marker is presented.
Original language | English |
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Title of host publication | RDD Europe 2017 |
Editors | R. N. Dalby, J. Peart, J. D. Suman, P. M. Young, D. Traini |
Place of Publication | Richmond, VA |
Publisher | RDD Online |
Pages | 401-404 |
Number of pages | 4 |
Volume | 2 |
ISBN (Electronic) | 9781942911067 |
Publication status | Published - 2017 |
Externally published | Yes |
Event | Respiratory Drug Delivery Europe 2017 - Antibes, France Duration: 25 Apr 2017 → 28 Apr 2017 |
Conference
Conference | Respiratory Drug Delivery Europe 2017 |
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Country/Territory | France |
City | Antibes |
Period | 25/04/17 → 28/04/17 |
Keywords
- Na decanoate
- tight junction
- epithelial cells
- calu-3 cells
- nebulizer
- para-cellular transport