Effect of the glycemic index of carbohydrates on acne vulgaris

Rebecca C. Reynolds, Stephen Lee, James Y J Choi, Fiona S. Atkinson, Karola S. Stockmann, Peter Petocz, Jennie C. Brand-Miller

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    Abstract

    Acne vulgaris may be improved by dietary factors that increase insulin sensitivity. We hypothesized that a low-glycemic index diet would improve facial acne severity and insulin sensitivity. Fifty-eight adolescent males (mean age ± standard deviation 16.5 ± 1.0 y and body mass index 23.1 ± 3.5 kg/m2) were alternately allocated to high or low glycemic index diets. Severity of inflammatory lesions on the face, insulin sensitivity (homeostasis modeling assessment of insulin resistance), androgens and insulin-like growth factor-1 and its binding proteins were assessed at baseline and at eight weeks, a period corresponding to the school term. Forty-three subjects (n = 23 low glycemic index and n = 20 high glycemic index) completed the study. Diets differed significantly in glycemic index (mean ± standard error of the mean, low glycemic index 51 ± 1 vs. high glycemic index 61 ± 2, p = 0.0002), but not in macronutrient distribution or fiber content. Facial acne improved on both diets (low glycemic index -26 ± 6%, p = 0.0004 and high glycemic index -16 ± 7%, p = 0.01), but differences between diets did not reach significance. Change in insulin sensitivity was not different between diets (low glycemic index 0.2 ± 0.1 and high glycemic index 0.1 ± 0.1, p = 0.60) and did not correlate with change in acne severity (Pearson correlation r = -0.196, p = 0.244). Longer time frames, greater reductions in glycemic load or/and weight loss may be necessary to detect improvements in acne among adolescent boys.

    Original languageEnglish
    Pages (from-to)1060-1072
    Number of pages13
    JournalNutrients
    Volume2
    Issue number10
    DOIs
    Publication statusPublished - Oct 2010

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  • Cite this

    Reynolds, R. C., Lee, S., Choi, J. Y. J., Atkinson, F. S., Stockmann, K. S., Petocz, P., & Brand-Miller, J. C. (2010). Effect of the glycemic index of carbohydrates on acne vulgaris. Nutrients, 2(10), 1060-1072. https://doi.org/10.3390/nu2101060