Effect of varying inflow conditions on pharmaceutical powder dynamics in inhaler-like flows

A. Lowe; G. Singh; A. Azeem; S. Cheng; H.-K. Chan; A. Kourmatzis

doi:10.14264/3adda97

Effect of varying inflow conditions on pharmaceutical powder dynamics in inhaler-like flows

A. Lowe, G. Singh, A. Azeem, S. Cheng, H.-K. Chan, A. Kourmatzis

School of Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution › peer-review

34 Downloads (Pure)

Abstract

The transport of pharmaceutical dry powders (mannitol) is investigated inside an optically accessible inhaler-like device, using both far and near-field high-speed microscopic backlit imaging. The device was designed to study the effect of intake flow modifications on the dispersion characteristics of common dry powder inhalers (DPIs). Design modifications included impaction grids, vortex/swirl paths and localized turbulence (inlet/outlet conditions). Quantitative imaging enabled the isolated investigation of particle-air flow interaction induced by these specific design features at realistic inhalation flowrates. This research forms a new platform to characterize the dynamic behavior of powder dispersion in DPIs and to help isolate fundamental mechanisms which enable effective powder dispersion.

Original language	English
Title of host publication	Proceedings of 22nd Australasian Fluid Mechanics Conference AFMC2020
Editors	Hubert Chanson, Richard Brown
Place of Publication	Brisbane
Publisher	The University of Queensland
Number of pages	4
ISBN (Electronic)	9781742723419
DOIs	https://doi.org/10.14264/3adda97
Publication status	Published - 2020
Event	Australasian Fluid Mechanics Conference (22nd : 2020) - Brisbane, Australia Duration: 7 Dec 2020 → 10 Dec 2020 Conference number: 22nd

Publication series

Name
ISSN (Electronic)	2653-0597

Conference

Conference	Australasian Fluid Mechanics Conference (22nd : 2020)
Abbreviated title	AFMC2020
Country/Territory	Australia
City	Brisbane
Period	7/12/20 → 10/12/20

Bibliographical note

Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

dry powder inhaler
swirl
grid
pharmaceutical drug

Access to Document

10.14264/3adda97Licence: CC BY-NC

Publisher version (open access)Final published version, 939 KBLicence: CC BY-NC

Cite this

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title = "Effect of varying inflow conditions on pharmaceutical powder dynamics in inhaler-like flows",

abstract = "The transport of pharmaceutical dry powders (mannitol) is investigated inside an optically accessible inhaler-like device, using both far and near-field high-speed microscopic backlit imaging. The device was designed to study the effect of intake flow modifications on the dispersion characteristics of common dry powder inhalers (DPIs). Design modifications included impaction grids, vortex/swirl paths and localized turbulence (inlet/outlet conditions). Quantitative imaging enabled the isolated investigation of particle-air flow interaction induced by these specific design features at realistic inhalation flowrates. This research forms a new platform to characterize the dynamic behavior of powder dispersion in DPIs and to help isolate fundamental mechanisms which enable effective powder dispersion.",

keywords = "dry powder inhaler, swirl, grid, pharmaceutical drug",

author = "A. Lowe and G. Singh and A. Azeem and S. Cheng and H.-K. Chan and A. Kourmatzis",

note = "Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.; Australasian Fluid Mechanics Conference (22nd : 2020), AFMC2020 ; Conference date: 07-12-2020 Through 10-12-2020",

year = "2020",

doi = "10.14264/3adda97",

language = "English",

publisher = "The University of Queensland",

editor = "Hubert Chanson and Richard Brown",

booktitle = "Proceedings of 22nd Australasian Fluid Mechanics Conference AFMC2020",

}

Lowe, A, Singh, G, Azeem, A, Cheng, S, Chan, H-K & Kourmatzis, A 2020, Effect of varying inflow conditions on pharmaceutical powder dynamics in inhaler-like flows. in H Chanson & R Brown (eds), Proceedings of 22nd Australasian Fluid Mechanics Conference AFMC2020., 48, The University of Queensland, Brisbane, Australasian Fluid Mechanics Conference (22nd : 2020), Brisbane, Queensland, Australia, 7/12/20. https://doi.org/10.14264/3adda97

Effect of varying inflow conditions on pharmaceutical powder dynamics in inhaler-like flows. / Lowe, A.; Singh, G.; Azeem, A. et al.

Proceedings of 22nd Australasian Fluid Mechanics Conference AFMC2020. ed. / Hubert Chanson; Richard Brown. Brisbane : The University of Queensland, 2020. 48.

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution › peer-review

TY - GEN

T1 - Effect of varying inflow conditions on pharmaceutical powder dynamics in inhaler-like flows

AU - Lowe, A.

AU - Singh, G.

AU - Azeem, A.

AU - Cheng, S.

AU - Chan, H.-K.

AU - Kourmatzis, A.

N1 - Conference code: 22nd

PY - 2020

Y1 - 2020

N2 - The transport of pharmaceutical dry powders (mannitol) is investigated inside an optically accessible inhaler-like device, using both far and near-field high-speed microscopic backlit imaging. The device was designed to study the effect of intake flow modifications on the dispersion characteristics of common dry powder inhalers (DPIs). Design modifications included impaction grids, vortex/swirl paths and localized turbulence (inlet/outlet conditions). Quantitative imaging enabled the isolated investigation of particle-air flow interaction induced by these specific design features at realistic inhalation flowrates. This research forms a new platform to characterize the dynamic behavior of powder dispersion in DPIs and to help isolate fundamental mechanisms which enable effective powder dispersion.

AB - The transport of pharmaceutical dry powders (mannitol) is investigated inside an optically accessible inhaler-like device, using both far and near-field high-speed microscopic backlit imaging. The device was designed to study the effect of intake flow modifications on the dispersion characteristics of common dry powder inhalers (DPIs). Design modifications included impaction grids, vortex/swirl paths and localized turbulence (inlet/outlet conditions). Quantitative imaging enabled the isolated investigation of particle-air flow interaction induced by these specific design features at realistic inhalation flowrates. This research forms a new platform to characterize the dynamic behavior of powder dispersion in DPIs and to help isolate fundamental mechanisms which enable effective powder dispersion.

KW - dry powder inhaler

KW - swirl

KW - grid

KW - pharmaceutical drug

UR - http://purl.org/au-research/grants/arc/DP190101237

U2 - 10.14264/3adda97

DO - 10.14264/3adda97

M3 - Conference proceeding contribution

BT - Proceedings of 22nd Australasian Fluid Mechanics Conference AFMC2020

A2 - Chanson, Hubert

A2 - Brown, Richard

PB - The University of Queensland

CY - Brisbane

T2 - Australasian Fluid Mechanics Conference (22nd : 2020)

Y2 - 7 December 2020 through 10 December 2020

ER -

Effect of varying inflow conditions on pharmaceutical powder dynamics in inhaler-like flows

Abstract

Publication series

Conference

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Particle transport in the human upper airway

Cite this

Effect of varying inflow conditions on pharmaceutical powder dynamics in inhaler-like flows

Abstract

Publication series

Conference

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Projects

Particle transport in the human upper airway

Cite this