Effect of varying inflow conditions on pharmaceutical powder dynamics in inhaler-like flows

A. Lowe, G. Singh, A. Azeem, S. Cheng, H.-K. Chan, A. Kourmatzis

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contributionpeer-review

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Abstract

The transport of pharmaceutical dry powders (mannitol) is investigated inside an optically accessible inhaler-like device, using both far and near-field high-speed microscopic backlit imaging. The device was designed to study the effect of intake flow modifications on the dispersion characteristics of common dry powder inhalers (DPIs). Design modifications included impaction grids, vortex/swirl paths and localized turbulence (inlet/outlet conditions). Quantitative imaging enabled the isolated investigation of particle-air flow interaction induced by these specific design features at realistic inhalation flowrates. This research forms a new platform to characterize the dynamic behavior of powder dispersion in DPIs and to help isolate fundamental mechanisms which enable effective powder dispersion.
Original languageEnglish
Title of host publicationProceedings of 22nd Australasian Fluid Mechanics Conference AFMC2020
EditorsHubert Chanson, Richard Brown
Place of PublicationBrisbane
PublisherThe University of Queensland
Number of pages4
ISBN (Electronic)9781742723419
DOIs
Publication statusPublished - 2020
EventAustralasian Fluid Mechanics Conference (22nd : 2020) - Brisbane, Australia
Duration: 7 Dec 202010 Dec 2020
Conference number: 22nd

Publication series

Name
ISSN (Electronic)2653-0597

Conference

ConferenceAustralasian Fluid Mechanics Conference (22nd : 2020)
Abbreviated titleAFMC2020
CountryAustralia
CityBrisbane
Period7/12/2010/12/20

Bibliographical note

Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • dry powder inhaler
  • swirl
  • grid
  • pharmaceutical drug

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