Effective inhibition of the early copper ion burst release with ultra-fine grained copper and single crystal copper for intrauterine device application

X. X. Xu, F. L. Nie, Y. B. Wang, J. X. Zhang, W. Zheng, L. Li, Y. F. Zheng*

*Corresponding author for this work

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

To solve the main problems of existing coarse grained copper (CG Cu) intrauterine devices (IUD) - namely burst release and a low transfer efficiency of the cupric ions during usage - ultra-fine grained copper (UFG Cu) and single crystal copper (SC Cu) have been investigated as potential substitutes. Their corrosion properties with CG Cu as a control have been studied in simulated uterine fluid (SUF) under different conditions using electrochemical measurement methods. Long-term immersion of UFG Cu, SC Cu and CG Cu samples in SUF at 37°C have been studied for 300 days. A lower copper ion burst release and a higher efficiency release of cupric ions were observed for UFG Cu and SC Cu compared with CG Cu in the first month of immersion and 2 months later. The respective corrosion mechanisms for UFG Cu, SC Cu and CG Cu in SUF are proposed. In vitro biocompatibility tests show a better cellular response to UFG Cu and SC Cu than CG Cu. In terms of instantaneous corrosion behavior, long-term corrosion performance and in vitro biocompatibility, the three pure copper materials follow the order: UFG Cu > SC Cu > CG Cu, which indicates that UFG Cu could be the most suitable candidate material for intrauterine devices.

Original languageEnglish
Pages (from-to)886-896
Number of pages11
JournalActa Biomaterialia
Volume8
Issue number2
DOIs
Publication statusPublished - Feb 2012
Externally publishedYes

Keywords

  • Biocompatibility
  • Copper
  • Corrosion
  • In vitro test
  • Metal ion release

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