Effects of a 2- to 4-week course of repetitive Transcranial Magnetic Stimulation (rTMS) on neuropsychologic functioning, electroencephalogram, and auditory threshold in depressed patients

Colleen Loo*, Perminder Sachdev, Hamada Elsayed, Benjamin McDarmont, Philip Mitchell, Monica Wilkinson, Gordon Parker, Simon Gandevia

*Corresponding author for this work

Research output: Contribution to journalArticle

116 Citations (Scopus)

Abstract

Background: The safety of repetitive transcranial magnetic stimulation (rTMS) has only previously been formally studied in volunteers receiving a single session of stimulation or in a small number of depressed subjects receiving a 2-week treatment course. This study examined safety issues in depressed subjects receiving up to 4 weeks of rTMS. Efficacy results from this study have been previously reported. Methods: Eighteen subjects with DSM-IV major depression participated in a 2-week, parallel, double-blind, sham-controlled study of rTMS treatment. Twelve subjects then went on to receive 4 weeks active rTMS in an open follow-up. We examined the effects of rTMS on neuropsychologic function (up to 4 weeks), auditory threshold (up to 6 weeks exposure to rTMS noise), and an electroencephalogram (after 2 weeks). Data were analyzed by repeated measures analysis. Results: There were trends for improvement in neuropsychologic performance, probably due to practice effects. No mean changes in auditory threshold occurred, but two patients showed mild high-frequency hearing loss after several weeks of rTMS. Electroencephalograms in two patients, one of whom had sham stimulation, showed minor abnormality. Conclusions: No significant mean deficits were demonstrated in this cohort. Overall, rTMS for up to 4 weeks is safe, but individual results suggest caution and the need for further investigation of the safety of several weeks of rTMS.

Original languageEnglish
Pages (from-to)615-623
Number of pages9
JournalBiological Psychiatry
Volume49
Issue number7
DOIs
Publication statusPublished - 1 Apr 2001

Keywords

  • EEG
  • Hearing
  • Neuropsychologic
  • Safety
  • Transcranial magnetic stimulation
  • Treatment

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