Effects of Cav3.2 channel mutations linked to idiopathic generalized epilepsy

Houman Khosravani, Christopher Bladen, David B. Parker, Terrance P. Snutch, John E. McRory, Gerald W. Zamponi

Research output: Contribution to journalArticlepeer-review

92 Citations (Scopus)

Abstract

Heron and colleagues (Ann Neurol 2004;55:595-596) identified three missense mutations in the Cav3.2 T-type calcium channel gene (CACNA1H) in patients with idiopathic generalized epilepsy. None of the variants were associated with a specific epilepsy phenotype and were not found in patients with juvenile absence epilepsy or childhood absence epilepsy. Here, we introduced and functionally characterized these three mutations using transiently expressed human Cav3.2 channels. Two of the mutations exhibited functional changes that are consistent with increased channel function. Taken together, these findings along with previous reports, strongly implicate CACNA1H as a susceptibility gene in complex idiopathic generalized epilepsy.
Original languageEnglish
Pages (from-to)745-749
Number of pages5
JournalAnnals of Neurology
Volume57
Issue number5
DOIs
Publication statusPublished - May 2005
Externally publishedYes

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