Effects of constitutive gene expression on the dynamics of random boolean networks

Jennifer Hallinan*, Daniel Bradley, Janet Wiles

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contributionpeer-review

2 Citations (Scopus)

Abstract

We investigate the effects of constitutive gene activation upon the dynamics of random Boolean networks using a suite of models. We find that constitutive activity leads to simpler state spaces, with fewer and larger basins of attraction. The major difference in patterns of basin number and distribution is seen between networks with no activation and those with a single constitutively active node. Increasing the proportion of constitutively active node intensifies, but does not qualitatively change, the observed patterns. The proportion of genes constitutively active interacts in a nonlinear way with other network parameters, such as average connectivity and proportion of inhibitory links. We conclude that constitutive gene activation has a fundamental effect on network behavior that has been overlooked in previous random Boolean network studies. It acts to constrain the start states of the networks, and the states which can be reached during development and differentiation, and we hypothesize that constitutive activation and repression of genes may help to guide the process whereby a single genetic regulatory network produces a range of different cell types.

Original languageEnglish
Title of host publication2006 IEEE Congress on Evolutionary Computation
Place of PublicationPiscataway, N.J.
PublisherInstitute of Electrical and Electronics Engineers (IEEE)
Pages2355-2361
Number of pages7
ISBN (Print)0780394879, 9780780394872
DOIs
Publication statusPublished - Jul 2006
Externally publishedYes
Event2006 IEEE Congress on Evolutionary Computation, CEC - 2006 - Vancouver, Canada
Duration: 16 Jul 200621 Jul 2006

Other

Other2006 IEEE Congress on Evolutionary Computation, CEC - 2006
CountryCanada
CityVancouver
Period16/07/0621/07/06

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