Effects of deslorelin implants on reproduction in the common brushtail possum (Trichosurus vulpecula)

Jutta Eymann, Catherine A. Herbert, Brian P. Thomson, Tim E. Trigg, Desmond W. Cooper, Douglas C. Eckery

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The present study investigated the effects of slow-release implants containing the gonadotrophin-releasing hormone (GnRH) agonist deslorelin on reproduction in the common brushtail possum (Trichosurus vulpecula). Captive female brushtail possums were assigned to control (placebo implant), low dose (4.7 mg deslorelin) or high dose (9.4 mg deslorelin) groups; males were assigned to control or high dose (9.4 mg deslorelin) groups. The acute effects of deslorelin treatment at the level of the pituitary gland were similar between the two sexes, where a transient rise in luteinising hormone concentration was induced over the first 24 h. In females, this was associated with the disruption of the normal oestrous cycle and mating within 2–10 days in some treated individuals, but no young were subsequently detected. By 3 weeks after treatment, treated females became anoestrus and remained infertile for at least one breeding season. The effects of treatment were reversible in a subset of females that had their implants removed, although the time taken to produce offspring was variable. Paradoxically, male brushtail possums remained fertile during chronic deslorelin exposure. Despite significant declines in basal follicle-stimulating hormone and testosterone concentrations, as well as an inability to respond to a GnRH challenge, treated males sired as many offspring as control males and there was no evidence of testicular regression. In conclusion, there is potential to control reproduction in female brushtail possums by using chronic GnRH agonist treatment.
Original languageEnglish
Pages (from-to)899-909
Number of pages11
JournalReproduction, Fertility and Development
Volume19
Issue number8
DOIs
Publication statusPublished - 2007

Keywords

  • contraception
  • endocrinology
  • fertility control
  • progesterone
  • vaginal cell cytology

Fingerprint Dive into the research topics of 'Effects of deslorelin implants on reproduction in the common brushtail possum (Trichosurus vulpecula)'. Together they form a unique fingerprint.

Cite this