Effects of non‐steroidal anti‐inflammatory drugs on prostacyclin and thromboxane biosynthesis in patients with mild essential hypertension.

P. Minuz*, SE Barrow, JR Cockcroft, JM Ritter

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

1. The effects of non‐steroidal anti‐inflammatory drugs (NSAID) on prostacyclin and thromboxane biosynthesis and on blood pressure were determined in 46 patients with mild essential hypertension. Patients who had abstained from antihypertensive therapy for 2 weeks before study were treated with either aspirin, ibuprofen, sulindac or placebo for 7 days. 2. Excretion rates of 2,3‐dinor‐6‐oxo‐prostaglandin (PG) F1 alpha, 6‐oxo‐PGF1 alpha, 2,3‐dinorthromboxane (TX) B2 and TXB2 were measured as indices of prostacyclin and TXA2 biosynthesis. Samples were assayed using immunoaffinity chromatography and gas chromatography/electron capture chemical ionisation mass spectrometry. 3. Aspirin and ibuprofen reduced urinary excretion of all prostacyclin‐ and thromboxane‐derived products. Sulindac inhibited excretion of 2,3‐ dinor‐6‐oxo‐PGF1 alpha, 6‐oxo‐PGF1 alpha and 2,3‐dinor‐TXB2, but had no significant effect on TXB2. 4. Systolic blood pressure increased in the ibuprofen‐treated group when compared with the placebo group. There were no other significant changes in systolic or diastolic pressure in any of the treatment groups. Among the patients as a whole, there was a significant negative correlation between change in blood pressure and change in excretion of the prostacyclin‐derived but not of the thromboxane‐derived products. 5. We conclude that, in patients with mild essential hypertension, neither sulindac nor aspirin (in the doses used) selectively spares prostacyclin biosynthesis by the kidney. The significant relationship between increase in blood pressure and reduction in prostacyclin biosynthesis favours the possibility that in individuals who become hypertensive, prostacyclin biosynthesis determines, in part, the severity of the hypertensive state. 1990 The British Pharmacological Society

Original languageEnglish
Pages (from-to)519-526
Number of pages8
JournalBritish Journal of Clinical Pharmacology
Volume30
Issue number4
DOIs
Publication statusPublished - 1990

Fingerprint

Dive into the research topics of 'Effects of non‐steroidal anti‐inflammatory drugs on prostacyclin and thromboxane biosynthesis in patients with mild essential hypertension.'. Together they form a unique fingerprint.

Cite this