Effects of online intervention for depression on mood and positive symptoms in schizophrenia

Steffen Moritz*, Johanna Schröder, Jan Philipp Klein, Tania M. Lincoln, Christina Andreou, Anja Fischer, Sönke Arlt

*Corresponding author for this work

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background Depression is common in schizophrenia. Whereas the improvement of mood and self-esteem represents a subjective treatment priority for many patients, depression is rarely a primary target for clinical intervention. The present trial examined whether an online intervention for depression can ameliorate depressive symptoms in schizophrenia. Methods A total of 58 individuals with schizophrenia were invited to participate in an online survey which encompassed the Center for Epidemiologic Studies-Depression Scale (CES-D, primary outcome), the Patient-Health-Questionnaire-9 (PHQ-9) and the Paranoia Checklist. Subsequently, telephone interviews were conducted to verify diagnostic status and assess symptoms (Positive and Negative Syndrome Scale, PANSS). Participants were randomized either to the experimental condition (online depression intervention) or to a waitlist control condition. Three months after inclusion, a reassessment was carried out (self-report and telephone interview blind for group condition). The trial was registered (registration: DRKS00007888). Results Participants in the treatment group showed a significant decline of depressive symptoms at a medium-to-large effect size, as assessed with the CES-D and the PANSS depression item, in comparison to the waitlist control group (completer (CC) and intention-to-treat analyses (ITT)). For the PHQ-9 (CC and ITT) and the PANSS distress subscale (CC only) significance was bordered at a medium effect size. Completion at the post-assessment after three months was 84%. Discussion Depression in schizophrenia is both underdiagnosed and undertreated. To reduce the large treatment gap in the disorder, low threshold strategies are urgently needed. Online treatment and bibliotherapy may represent valuable tools to address patients’ needs beyond the treatment of the core positive syndrome.

Original languageEnglish
Pages (from-to)216-222
Number of pages7
JournalSchizophrenia Research
Volume175
Issue number1-3
DOIs
Publication statusPublished - Aug 2016
Externally publishedYes

Keywords

  • Schizophrenia
  • Depression
  • Online intervention
  • Self-help
  • Psychosis

Fingerprint Dive into the research topics of 'Effects of online intervention for depression on mood and positive symptoms in schizophrenia'. Together they form a unique fingerprint.

  • Cite this

    Moritz, S., Schröder, J., Klein, J. P., Lincoln, T. M., Andreou, C., Fischer, A., & Arlt, S. (2016). Effects of online intervention for depression on mood and positive symptoms in schizophrenia. Schizophrenia Research, 175(1-3), 216-222. https://doi.org/10.1016/j.schres.2016.04.033