TY - JOUR
T1 - Effects of peptide YY on the human cardiovascular system
T2 - Reversal of responses to vasoactive intestinal peptide
AU - Playford, R. J.
AU - Benito-Orfila, M. A.
AU - Nihoyannopoulos, P.
AU - Nandha, K. A.
AU - Cockcroft, J.
AU - Todd, S.
AU - Ghatei, M. A.
AU - Domin, J.
AU - Bloom, S. R.
AU - Calam, J.
PY - 1992
Y1 - 1992
N2 - Peptide YY (PYY) reverses the increased intestinal secretion stimulated by vasoactive intestinal peptide (VIP) in humans. VIP also dilates blood vessels, so we investigated the effect of PYY on the cardiovascular system. Six volunteers received PYY, 0.4 and 1.2 pmol · kg-1 · min-1 iv for 2 h, reproducing plasma levels seen postprandially and during a diarrheal illness, respectively. Cardiac function was assessed by echocardiography. PYY infused at 0.4 pmol · kg-1 · min-1 had no effect on cardiovascular parameters. PYY infused at 1.2 pmol · kg-1 · min-1 caused a fall in both stroke volume from 128 ± 8 to 110 ± 8 ml/beat (mean ± 95 confidence interval, P < 0.01) and cardiac output from 7.2 ± 0.4 to 6.1 ± 0.4 l/min (P < 0.01). Effects of infusion of PYY into the brachial artery at doses of 0-16 pmol/min were assessed using venous occlusion plethysmography in six subjects. PYY infusion caused a dose-dependent fall in forearm blood flow. Six subjects received VIP, 5 pmol · kg-1 · min-1 iv, causing a rise in heart rate from 55 ± 3 to 70 ± 3 beats/min and increased cardiac output from 7.3 ± 1.1 to 13.1 ± 1.1 l/min. The addition of PYY, 0.4 pmol · kg-1 · min-1 iv, did not affect the heart rate significantly but decreased the cardiac output to 10.4 ± 1.1 l/min (P < 0.01). Infusions of PYY into the brachial artery at 5 pmol/min decreased local vasodilation induced by VIP infused at 2 pmol/min at the same site by 40% (P < 0.01), even though this dose of PYY had no significant effect on local blood flow when given alone. These results suggest that PYY may contribute to normal physiological control of cardiovascular function and that PYY has a vasoconstrictor effect in humans at plasma concentrations seen during a diarrheal illness.
AB - Peptide YY (PYY) reverses the increased intestinal secretion stimulated by vasoactive intestinal peptide (VIP) in humans. VIP also dilates blood vessels, so we investigated the effect of PYY on the cardiovascular system. Six volunteers received PYY, 0.4 and 1.2 pmol · kg-1 · min-1 iv for 2 h, reproducing plasma levels seen postprandially and during a diarrheal illness, respectively. Cardiac function was assessed by echocardiography. PYY infused at 0.4 pmol · kg-1 · min-1 had no effect on cardiovascular parameters. PYY infused at 1.2 pmol · kg-1 · min-1 caused a fall in both stroke volume from 128 ± 8 to 110 ± 8 ml/beat (mean ± 95 confidence interval, P < 0.01) and cardiac output from 7.2 ± 0.4 to 6.1 ± 0.4 l/min (P < 0.01). Effects of infusion of PYY into the brachial artery at doses of 0-16 pmol/min were assessed using venous occlusion plethysmography in six subjects. PYY infusion caused a dose-dependent fall in forearm blood flow. Six subjects received VIP, 5 pmol · kg-1 · min-1 iv, causing a rise in heart rate from 55 ± 3 to 70 ± 3 beats/min and increased cardiac output from 7.3 ± 1.1 to 13.1 ± 1.1 l/min. The addition of PYY, 0.4 pmol · kg-1 · min-1 iv, did not affect the heart rate significantly but decreased the cardiac output to 10.4 ± 1.1 l/min (P < 0.01). Infusions of PYY into the brachial artery at 5 pmol/min decreased local vasodilation induced by VIP infused at 2 pmol/min at the same site by 40% (P < 0.01), even though this dose of PYY had no significant effect on local blood flow when given alone. These results suggest that PYY may contribute to normal physiological control of cardiovascular function and that PYY has a vasoconstrictor effect in humans at plasma concentrations seen during a diarrheal illness.
KW - vascular resistance
KW - vasoconstrictor agents
UR - http://www.scopus.com/inward/record.url?scp=0026785895&partnerID=8YFLogxK
U2 - 10.1152/ajpendo.1992.263.4.E740
DO - 10.1152/ajpendo.1992.263.4.E740
M3 - Article
C2 - 1415694
AN - SCOPUS:0026785895
SN - 0193-1849
VL - 263
SP - E740-E747
JO - American Journal of Physiology - Endocrinology and Metabolism
JF - American Journal of Physiology - Endocrinology and Metabolism
IS - 4
ER -