Effects of Phyllanthus plant extracts on duck hepatitis B virus in vitro and in vivo

Andrew Shead*, Karen Vickery, Aniko Pajkos, Robert Medhurst, John Freiman, Robert Dixon, Yvonne Cossart

*Corresponding author for this work

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

The effects of extracts of five Australian Phyllanthus species (P. hirtellus, P. gunnii, P. gasstroemii, P. similis and P. tenellus), other plant extracts and the antiviral drug foscarnet on duck hepatitis B virus (DHBV) endogenous DNA polymerase (DNAp) activity were compared. All 5 Phyllanthus species caused 50% inhibition at concentrations of dry weight between 350-800 μg/ml, which is comparable with the effect described for P. amarus on the DNAp of human and woodchuck hepatitis B viruses. Incubation of P. hirtellus with 100 ID50 DHBV neutralized infection. However, neither P. gasstroemi extract, given by intraperitoneal injection (i.p.) at a dose of 20 mg/kg 3 times per week to ducklings early in the incubation period, or P. hirtellus extract, given to established DHBV carrier ducklings, prevented or eliminated infection.

Original languageEnglish
Pages (from-to)127-138
Number of pages12
JournalAntiviral Research
Volume18
Issue number2
DOIs
Publication statusPublished - 1992
Externally publishedYes

Keywords

  • DNA polymerase
  • Duck hepatitis B
  • Neutralization
  • Phyllanthus

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