Effects of steroids and lubricants on electrical impedance and tissue response following cochlear implantation

Christie Qi Huang, Michael Tykocinski*, Dimitra Stathopoulos, Robert Cowan

*Corresponding author for this work

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The present study examined the effects of steroids and lubricants on electrical impedance and tissue response following cochlear implantation in animal models. Guinea pigs were implanted following either no treatment, or intrascalar injection with dexamethasone, triamcinolone, sodium hyaluronate or saline. Cats were implanted following either no treatment, or intrascalar injection with dexamethasone, triamcinolone or a mixture of triamcinolone with sodium hyaluronate. In guinea pigs, impedance changes and intracochlear tissue response were less for the hyaluronate and saline groups. In cats, impedance in the dexamethasone group increased similar to non-treated cats. Impedance of triamcinolone treated cats remained low for about two months after implantation, before increasing to levels similar to the other groups. Significant fibrous tissue growth was observed histologically. The results of the present study indicate that a single intracochlear application of hyaluronate or triamcinolone may postpone, but will ultimately not prevent the rise in impedance following cochlear implantation.

Original languageEnglish
Pages (from-to)123-147
Number of pages25
JournalCochlear implants international
Volume8
Issue number3
DOIs
Publication statusPublished - 2007
Externally publishedYes

Keywords

  • Cochlear implantation
  • Fibrous tissue growth
  • Impedance
  • Intracochlear electrodes

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