TY - JOUR
T1 - Effects of steroids and lubricants on electrical impedance and tissue response following cochlear implantation
AU - Huang, Christie Qi
AU - Tykocinski, Michael
AU - Stathopoulos, Dimitra
AU - Cowan, Robert
PY - 2007
Y1 - 2007
N2 - The present study examined the effects of steroids and lubricants on electrical impedance and tissue response following cochlear implantation in animal models. Guinea pigs were implanted following either no treatment, or intrascalar injection with dexamethasone, triamcinolone, sodium hyaluronate or saline. Cats were implanted following either no treatment, or intrascalar injection with dexamethasone, triamcinolone or a mixture of triamcinolone with sodium hyaluronate. In guinea pigs, impedance changes and intracochlear tissue response were less for the hyaluronate and saline groups. In cats, impedance in the dexamethasone group increased similar to non-treated cats. Impedance of triamcinolone treated cats remained low for about two months after implantation, before increasing to levels similar to the other groups. Significant fibrous tissue growth was observed histologically. The results of the present study indicate that a single intracochlear application of hyaluronate or triamcinolone may postpone, but will ultimately not prevent the rise in impedance following cochlear implantation.
AB - The present study examined the effects of steroids and lubricants on electrical impedance and tissue response following cochlear implantation in animal models. Guinea pigs were implanted following either no treatment, or intrascalar injection with dexamethasone, triamcinolone, sodium hyaluronate or saline. Cats were implanted following either no treatment, or intrascalar injection with dexamethasone, triamcinolone or a mixture of triamcinolone with sodium hyaluronate. In guinea pigs, impedance changes and intracochlear tissue response were less for the hyaluronate and saline groups. In cats, impedance in the dexamethasone group increased similar to non-treated cats. Impedance of triamcinolone treated cats remained low for about two months after implantation, before increasing to levels similar to the other groups. Significant fibrous tissue growth was observed histologically. The results of the present study indicate that a single intracochlear application of hyaluronate or triamcinolone may postpone, but will ultimately not prevent the rise in impedance following cochlear implantation.
KW - Cochlear implantation
KW - Fibrous tissue growth
KW - Impedance
KW - Intracochlear electrodes
UR - http://www.scopus.com/inward/record.url?scp=34848841188&partnerID=8YFLogxK
U2 - 10.1002/cii.336
DO - 10.1002/cii.336
M3 - Article
C2 - 17854099
AN - SCOPUS:34848841188
SN - 1467-0100
VL - 8
SP - 123
EP - 147
JO - Cochlear Implants International
JF - Cochlear Implants International
IS - 3
ER -