Effects of tracer blood measurement noise on glucose metabolic rate estimation

D. Feng; X. Wang; R. Fulton; B. Hutton; J. Morris

Effects of tracer blood measurement noise on glucose metabolic rate estimation

D. Feng^*, X. Wang, R. Fulton, B. Hutton, J. Morris

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Tracer kinetic modeling with Positron Emission Tomography (PET) requires measurements of the time-activity curves in both plasma (PTAC) and tissue (TTAC) to estimate physiological parameters. However, the estimation usually ignores the measurement noise in plasma tracer activity curves. The accuracy and reliability of the physiological parameters estimated by ignoring such noise are not well understood. In this paper, computer simulations were performed to investigate the influence of input measurement noise on the accuracy of estimates. The results show that input measurement noise causes considerable variability in the parameter estimates.

Original language	English
Pages (from-to)	43-48
Number of pages	6
Journal	Biomedical Sciences Instrumentation
Volume	27
Publication status	Published - 1991

Cite this

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title = "Effects of tracer blood measurement noise on glucose metabolic rate estimation",

abstract = "Tracer kinetic modeling with Positron Emission Tomography (PET) requires measurements of the time-activity curves in both plasma (PTAC) and tissue (TTAC) to estimate physiological parameters. However, the estimation usually ignores the measurement noise in plasma tracer activity curves. The accuracy and reliability of the physiological parameters estimated by ignoring such noise are not well understood. In this paper, computer simulations were performed to investigate the influence of input measurement noise on the accuracy of estimates. The results show that input measurement noise causes considerable variability in the parameter estimates.",

author = "D. Feng and X. Wang and R. Fulton and B. Hutton and J. Morris",

year = "1991",

language = "English",

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journal = "Biomedical Sciences Instrumentation",

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T1 - Effects of tracer blood measurement noise on glucose metabolic rate estimation

AU - Feng, D.

AU - Wang, X.

AU - Fulton, R.

AU - Hutton, B.

AU - Morris, J.

PY - 1991

Y1 - 1991

N2 - Tracer kinetic modeling with Positron Emission Tomography (PET) requires measurements of the time-activity curves in both plasma (PTAC) and tissue (TTAC) to estimate physiological parameters. However, the estimation usually ignores the measurement noise in plasma tracer activity curves. The accuracy and reliability of the physiological parameters estimated by ignoring such noise are not well understood. In this paper, computer simulations were performed to investigate the influence of input measurement noise on the accuracy of estimates. The results show that input measurement noise causes considerable variability in the parameter estimates.

AB - Tracer kinetic modeling with Positron Emission Tomography (PET) requires measurements of the time-activity curves in both plasma (PTAC) and tissue (TTAC) to estimate physiological parameters. However, the estimation usually ignores the measurement noise in plasma tracer activity curves. The accuracy and reliability of the physiological parameters estimated by ignoring such noise are not well understood. In this paper, computer simulations were performed to investigate the influence of input measurement noise on the accuracy of estimates. The results show that input measurement noise causes considerable variability in the parameter estimates.

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M3 - Article

C2 - 2065176

AN - SCOPUS:0025859961

SN - 0067-8856

VL - 27

SP - 43

EP - 48

JO - Biomedical Sciences Instrumentation

JF - Biomedical Sciences Instrumentation

ER -

Effects of tracer blood measurement noise on glucose metabolic rate estimation

Abstract

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