Effects of tulathromycin (Draxxin) on contractility of isolated myometrium in rats

Mehrdad Neshat Gharamaleki*, Azarmi Yagoob, Safarmashaei Saeid, Sina Shadfar

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Tulathromycin that used as trade name of Draxxin in market is an active part of drug and belonged to new macrolide classes named triamilides, this drug has been using in veterinary broadly. In this study (interventional & descriptive) about 84 female Wistar rats (250-300 g) were selected and divided to 14 groups (n= 6). In first group; oxytocin plus Tulathromycin and in second group KCl plus Tulathromycin were used. Probably Tulathromycin blocks the entrance of calcium and calcium dependent contraction pathway in the uterus. The effects of Tulathromycin are reversible and dose dependent. In the existence of Tulathromycin the dose responsive curve of calcium contraction reduced significantly (p≤0.05). The result of this study showed that Tulathromycin can used for treatment of preterm labour and inhibition of parturition. Indeed the approving of abovementioned hypothesis in clinical trials needs to more investigation because the actual dosage of drug and pregnancy induced side effects must be recognized.
Original languageEnglish
Pages (from-to)496-500
Number of pages5
JournalMiddle East Journal of Scientific Research
Volume10
Issue number4
Publication statusPublished - 2011
Externally publishedYes

Keywords

  • Tulathromycin
  • Uterus
  • Rat

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