Effects of upright and supine position on cardiac rest and exercise response in aortic regurgitation

Wei Feng Shen, Gary S. Roubin, Peter J. Fletcher, Christopher Y P Choong, Brian F. Hutton, Phillip J. Harris, David T. Kelly*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    7 Citations (Scopus)

    Abstract

    The effects of upright and supine position on cardiac response to exercise were assessed by radionuclide ventriculography in 15 patients with moderate to severe aortic regurgitation (AR) and in 10 control subjects. In patients with AR, heart rate was higher during upright exercise, but systolic and diastolic blood pressure and left ventricular (LV) output were similar during both forms of exercise. LV stroke volume and end-diastolic volume were not altered during supine exercise. LV end-systolic volume increased and ejection fraction decreased during supine exercise, but both were unchanged during upright exercise. Of 15 patients, 5 in the upright and 12 in the supine position had an abnormal LV ejection fraction response to exercise (p < 0.01). Right ventricular ejection fraction increased and regurgitant index decreased with both forms of exercise and was not significantly different between the 2 positions. Thus, posture is important in determining LV response to exercise in patients with moderate to severe AR.

    Original languageEnglish
    Pages (from-to)428-431
    Number of pages4
    JournalThe American Journal of Cardiology
    Volume55
    Issue number4
    DOIs
    Publication statusPublished - 1 Feb 1985

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