Efficacy of face masks and respirators in preventing upper respiratory tract bacterial colonization and co-infection in hospital healthcare workers

C. Raina MacIntyre, Quanyi Wang, Bayzidur Rahman, Holly Seale, Iman Ridda, Zhanhai Gao, Peng Yang, Weixian Shi, Xinghuo Pang, Yi Zhang, Aye Moa*, Dominic E. Dwyer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

58 Citations (Scopus)
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Abstract

Objective: We compared the efficacy of medical masks (MM) and N95 respirators (N95) in preventing bacterial colonization/infection in healthcare workers (HCWs). Methods: A cluster randomized clinical trial (RCT) of 1441 hospital HCWs randomized to medical masks or N95 respirators, and compared to 481 control HCWs, was performed in Beijing, China, during the winter season of 2008-2009. Participants were followed for development of clinical respiratory illness (CRI). Symptomatic subjects were tested for Streptococcus pneumoniae, Bordetella pertussis, Chlamydia pneumoniae, Mycoplasma pneumoniae or Haemophilus influenza type B by multiplex polymerase chain reaction (PCR). Results: The rate of bacterial colonization was 2.8% in the N95 group (p = 0.02), 5.3% among medical mask users (p. <. 0.01) and 7.5% among the controls (p = 0.16). N95 respirators were significantly protective (adjusted RR 0.34, 95% CI: 0.21-0.56) against bacterial colonization. Co-infections of two bacteria or a virus and bacteria occurred in up to 3.7% of HCWs, and were significantly lower in the N95 arm. Conclusions: N95 respirators were significantly protective against bacterial colonization, co-colonization and viral-bacterial co-infection. We showed that dual respiratory virus or bacterial-viral co-infections can be reduced by the use of N95 respirators. This study has occupational health and safety implications for health workers.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalPreventive Medicine
Volume62
DOIs
Publication statusPublished - May 2014
Externally publishedYes

Bibliographical note

Copyright the Author(s) 2014. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.
A Corrigendum exists for this article and can be found in Preventative Medicine (2014) Vol 69, p. 165 at doi: 10.1016/j.ypmed.2014.09.022

Keywords

  • Bacterial colonization
  • Healthcare workers
  • Hospitals
  • N95 respirators and medical masks

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