Efficacy of peptide nucleic acid and selected conjugates against specific cellular pathologies of amyotrophic lateral sclerosis

Elisse C. Browne, Sonam Parakh, Luke F. Duncan, Steven J. Langford, Julie D. Atkin, Belinda M. Abbott

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Cellular studies have been undertaken on a nonamer peptide nucleic acid (PNA) sequence, which binds to mRNA encoding superoxide dismutase 1, and a series of peptide nucleic acids conjugated to synthetic lipophilic vitamin analogs including a recently prepared menadione (vitamin K) analog. Reduction of both mutant superoxide dismutase 1 inclusion formation and endoplasmic reticulum stress, two of the key cellular pathological hallmarks in amyotrophic lateral sclerosis, by two of the prepared PNA oligomers is reported for the first time.

LanguageEnglish
Pages1520-1527
Number of pages8
JournalBioorganic and Medicinal Chemistry
Volume24
Issue number7
DOIs
Publication statusPublished - 1 Apr 2016

Fingerprint

Peptide Nucleic Acids
Amyotrophic Lateral Sclerosis
Pathology
Superoxide Dismutase
Nucleic acid sequences
Vitamin K 3
Endoplasmic Reticulum Stress
Vitamin K
Oligomers
Vitamins
Messenger RNA
Superoxide Dismutase-1

Keywords

  • Peptide nucleic acid
  • Amyotrophic lateral sclerosis
  • Vitamin conjugation

Cite this

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Efficacy of peptide nucleic acid and selected conjugates against specific cellular pathologies of amyotrophic lateral sclerosis. / Browne, Elisse C.; Parakh, Sonam; Duncan, Luke F.; Langford, Steven J.; Atkin, Julie D.; Abbott, Belinda M.

In: Bioorganic and Medicinal Chemistry, Vol. 24, No. 7, 01.04.2016, p. 1520-1527.

Research output: Contribution to journalArticleResearchpeer-review

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