TY - JOUR
T1 - Efficacy of peptide nucleic acid and selected conjugates against specific cellular pathologies of amyotrophic lateral sclerosis
AU - Browne, Elisse C.
AU - Parakh, Sonam
AU - Duncan, Luke F.
AU - Langford, Steven J.
AU - Atkin, Julie D.
AU - Abbott, Belinda M.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Cellular studies have been undertaken on a nonamer peptide nucleic acid (PNA) sequence, which binds to mRNA encoding superoxide dismutase 1, and a series of peptide nucleic acids conjugated to synthetic lipophilic vitamin analogs including a recently prepared menadione (vitamin K) analog. Reduction of both mutant superoxide dismutase 1 inclusion formation and endoplasmic reticulum stress, two of the key cellular pathological hallmarks in amyotrophic lateral sclerosis, by two of the prepared PNA oligomers is reported for the first time.
AB - Cellular studies have been undertaken on a nonamer peptide nucleic acid (PNA) sequence, which binds to mRNA encoding superoxide dismutase 1, and a series of peptide nucleic acids conjugated to synthetic lipophilic vitamin analogs including a recently prepared menadione (vitamin K) analog. Reduction of both mutant superoxide dismutase 1 inclusion formation and endoplasmic reticulum stress, two of the key cellular pathological hallmarks in amyotrophic lateral sclerosis, by two of the prepared PNA oligomers is reported for the first time.
KW - Peptide nucleic acid
KW - Amyotrophic lateral sclerosis
KW - Vitamin conjugation
UR - http://www.scopus.com/inward/record.url?scp=84975763567&partnerID=8YFLogxK
UR - http://purl.org/au-research/grants/arc/DP0771578
U2 - 10.1016/j.bmc.2016.02.022
DO - 10.1016/j.bmc.2016.02.022
M3 - Article
C2 - 26935939
AN - SCOPUS:84975763567
VL - 24
SP - 1520
EP - 1527
JO - Bioorganic and Medicinal Chemistry
JF - Bioorganic and Medicinal Chemistry
SN - 0968-0896
IS - 7
ER -